Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KHK | P50053 | 7/20 | 0.39 |
| ▸ | TP53 | P04637 | 2/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | KCNJ6 | P48051 | 2/20 | 0.37 |
| ▸ | KCNJ5 | P48544 | 2/20 | 0.37 |
| ▸ | KCNJ3 | P48549 | 2/20 | 0.37 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.36 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.36 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.36 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.36 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.36 |
| ▸ | RPA1 | P27694 | 1/20 | 0.36 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.36 |
| ▸ | IDO1 | P14902 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29395344 | 0.89 | SCN9A (0.40) | KHKNPC1LMNAMAPTALOX15 | |
| SCHEMBL24543145 | 0.89 | SCN9A (0.40) | KHKNPC1LMNAMAPTALOX15 | |
| SCHEMBL22567226 | 0.87 | SMN1; SMN2 (0.40) | KHKNPC1LMNAMAPTALOX15 | |
| SCHEMBL22559656 | 0.86 | KHK (0.51) | KHKTP53NPC1LMNAMAPT | |
| Hydrochloric Acid SCHEMBL29677239 | 0.86 | SMN1; SMN2 (0.39) | KHKNPC1LMNAMAPTALOX15 | |
| SCHEMBL28685024 | 0.83 | KHK (0.38) | KHKTP53NPC1LMNAMAPT | |
| SCHEMBL28685022 | 0.83 | KHK (0.38) | KHKTP53NPC1LMNAMAPT | |
| SCHEMBL22559680 | 0.79 | NPC1 (0.41) | KHKTP53NPC1LMNAMAPT | |
| SCHEMBL22559621 | 0.79 | KHK (0.59) | KHKTP53NPC1MAPTRAB9A | |
| SCHEMBL22559640 | 0.79 | KHK (0.41) | KHKTP53NPC1LMNAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3955914-A1 | NOVEL COMPOUNDS AND METHODS OF USE TREATING FRUCTOSE-RELATED DISORDERS OR DISEASES | Colorado Research Partners, LLC (US) | 2022-02-23 | — | — | EP | disclosed |
| WO-2020215022-A1 | NOVEL COMPOUNDS AND METHODS OF USE TREATING FRUCTOSE-RELATED DISORDERS OR DISEASES | COLORADO RESEARCH PARTNERS, LLC (US) | 2020-10-22 | — | — | WO | disclosed |