Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EZH2 | Q15910 | 20/20 | 0.84 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.84 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.84 |
| ▸ | KDM1A | O60341 | 1/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21862648 | 0.98 | EZH2 (0.88) | EZH2CYP2D6CYP2C19KDM1A | |
| SCHEMBL17136202 | 0.94 | EZH2 (0.96) | EZH2CYP2D6CYP2C19 | |
| SCHEMBL17136207 | 0.94 | EZH2 (0.96) | EZH2CYP2D6CYP2C19 | |
| SCHEMBL15700495 | 0.94 | EZH2 (0.96) | EZH2CYP2D6CYP2C19 | |
| SCHEMBL22561535 | 0.93 | EZH2 (0.79) | EZH2CYP2D6CYP2C19 | |
| SCHEMBL18736287 | 0.91 | EZH2 (0.89) | EZH2CYP2D6CYP2C19KDM1A | |
| SCHEMBL16476033 | 0.91 | EZH2 (1.00) | EZH2CYP2D6CYP2C19 | |
| SCHEMBL15647852 | 0.91 | EZH2 (1.00) | EZH2CYP2D6CYP2C19 | |
| SCHEMBL15647850 | 0.91 | EZH2 (1.00) | EZH2CYP2D6CYP2C19 | |
| SCHEMBL22561466 | 0.91 | EZH2 (0.76) | EZH2CYP2D6CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3725314-A1 | SUBSTITUTED BENZENE COMPOUNDS | Epizyme, Inc. (US) | 2020-10-21 | — | — | EP | disclosed |