Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAF1 | P04049 | 16/20 | 0.51 |
| ▸ | BRAF | P15056 | 15/20 | 0.51 |
| ▸ | ABL1 | P00519 | 1/20 | 0.47 |
| ▸ | MAPK14 | Q16539 | 3/20 | 0.44 |
| ▸ | LCK | P06239 | 1/20 | 0.44 |
| ▸ | CSF1R | P07333 | 1/20 | 0.44 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19328136 | 0.90 | RAF1 (0.57) | RAF1BRAF | |
| SCHEMBL19328040 | 0.90 | RAF1 (0.59) | RAF1BRAF | |
| SCHEMBL19327962 | 0.90 | RAF1 (0.58) | RAF1BRAF | |
| SCHEMBL19328074 | 0.90 | RAF1 (0.55) | RAF1BRAFMAPK14LCKCSF1R | |
| SCHEMBL19328082 | 0.90 | RAF1 (0.65) | RAF1BRAF | |
| SCHEMBL19327912 | 0.90 | RAF1 (0.57) | RAF1BRAF | |
| SCHEMBL19328109 | 0.89 | RAF1 (0.58) | RAF1BRAF | |
| SCHEMBL19328035 | 0.89 | RAF1 (0.61) | RAF1BRAF | |
| SCHEMBL19328006 | 0.88 | RAF1 (0.58) | RAF1BRAF | |
| SCHEMBL22561962 | 0.86 | RAF1 (0.52) | RAF1BRAFABL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3191467-B1 | COMPOUNDS AND COMPOSITIONS AS KINASE INHIBITORS | NOVARTIS AG (CH) | 2020-10-21 | — | — | EP | disclosed |