SCHEMBL22566093

SCHEMBL22566093

N#Cc1ccc(O[C@H]2C[C@H]3C[C@@H](NC(=O)c4cnc(Cl)cn4)C[C@H]3C2)cc1Cl

nearest known ligand 0.55

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
AR P10275 19/20 0.55
PGR P06401 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL22556964 0.89 AR (0.69) ARPGR
SCHEMBL22556963 0.89 AR (0.69) ARPGR
SCHEMBL22565604 0.89 AR (0.69) ARPGR
SCHEMBL29913793 0.89 AR (0.69) ARPGR
SCHEMBL22565744 0.89 AR (0.66) ARPGR
SCHEMBL22565757 0.86 AR (0.62) ARPGR
SCHEMBL22565785 0.84 AR (0.57) ARPGR
SCHEMBL22565743 0.83 AR (0.80) ARPGR
SCHEMBL22565756 0.82 AR (0.55) ARPGR
SCHEMBL22557033 0.82 AR (0.43) ARPGR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2020211822-A1 A CLASS OF BIFUNCTIONAL CHIMERIC HETEROCYCLIC COMPOUNDS FOR TARGETED DEGRADATION OF ANDROGEN RECEPTORS AND USE THEREOF 成都海创药业有限公司 2020-10-22 WO disclosed