Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 1/20 | 0.48 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | CCR2 | P41597 | 1/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
| ▸ | TACR2 | P21452 | 1/20 | 0.40 |
| ▸ | TACR1 | P25103 | 1/20 | 0.39 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.38 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | CACNA2D1 | P54289 | 1/20 | 0.38 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.38 |
| ▸ | CACNB1 | Q02641 | 1/20 | 0.38 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.38 |
| ▸ | ACHE | P22303 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21949424 | 0.82 | HRH3 (0.49) | KCNH2TACR1HRH3ALDH1A1ATM | |
| SCHEMBL10042371 | 0.79 | CHRM5 (0.59) | SMN1; SMN2CHRM5ADRA2CACHE | |
| SCHEMBL20328015 | 0.77 | HRH3 (0.45) | KCNH2TACR1HRH3ALDH1A1KDM4E | |
| SCHEMBL24723762 | 0.75 | CHRM5 (0.50) | SIGMAR1SMN1; SMN2CHRM5ADRA2CACHE | |
| SCHEMBL22520624 | 0.74 | CACNA2D1 (0.43) | HSD11B1CCR2KCNH2HRH3ALDH1A1 | |
| SCHEMBL27012385 | 0.74 | CACNA2D1 (0.43) | SIGMAR1SMN1; SMN2KCNH2HRH3ALDH1A1 | |
| SCHEMBL24952740 | 0.74 | CHRM5 (0.50) | SIGMAR1SMN1; SMN2CCR2KCNH2HRH3 | |
| SCHEMBL27057099 | 0.73 | KDM4E (0.54) | KCNH2HRH3ALDH1A1ATMKDM4E | |
| SCHEMBL26700877 | 0.72 | NPC1 (0.38) | SIGMAR1KCNH2TACR2HRH3ALDH1A1 | |
| SCHEMBL27258955 | 0.72 | SMN1; SMN2 (0.51) | HSD11B1SIGMAR1SMN1; SMN2ALDH1A1CHRM5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20200331925-A1 | HETEROCYCLIC COMPOUNDS FOR THE TREATMENT OF ABNORMAL CELLULAR PROLIFERATION | G1 THERAPEUTICS, INC. (US) | 2020-10-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200331925-A1 | HETEROCYCLIC COMPOUNDS FOR THE TREATMENT OF ABNORMAL CELLULAR PROLIFERATION | MKI67, CCNC, CCNI | HSD11B1 1449/4885SIGMAR1 4335/4885SMN1; SMN2 2209/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.