Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE1B | Q01064 | 20/20 | 0.60 |
| ▸ | PDE1C | Q14123 | 15/20 | 0.60 |
| ▸ | PDE1A | P54750 | 13/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22574833 | 0.91 | PDE1B (0.61) | PDE1BPDE1CPDE1A | |
| SCHEMBL30087531 | 0.82 | PDE1B (0.70) | PDE1BPDE1CPDE1A | |
| SCHEMBL22574765 | 0.82 | PDE1B (0.70) | PDE1BPDE1CPDE1A | |
| SCHEMBL22574783 | 0.82 | PDE1B (0.70) | PDE1BPDE1CPDE1A | |
| SCHEMBL22574831 | 0.76 | PDE1B (0.62) | PDE1BPDE1CPDE1A | |
| SCHEMBL30672618 | 0.76 | PDE1B (0.62) | PDE1BPDE1CPDE1A | |
| SCHEMBL22574778 | 0.76 | PDE1B (0.62) | PDE1BPDE1CPDE1A | |
| SCHEMBL22574779 | 0.76 | PDE1B (0.62) | PDE1BPDE1CPDE1A | |
| SCHEMBL30672635 | 0.76 | PDE1B (0.62) | PDE1BPDE1CPDE1A | |
| SCHEMBL22878518 | 0.76 | PDE1B (1.00) | PDE1BPDE1CPDE1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11535611-B2 | Pyrazolo[3,4-B]pyridines and imidazo[1,5-B]pyridazines as PDE1 inhibitors | H. LUNDBECK A/S (DK) | 2022-12-27 | — | — | US | disclosed |
| US-20210009571-A1 | PYRAZOLO[3,4-B]PYRIDINES AND IMIDAZO[1,5-B]PYRIDAZINES AS PDE1 INHIBITORS | H. LUNDBECK A/S (DK) | 2021-01-14 | — | — | US | disclosed |
| EP-3728250-A1 | PYRAZOLO[3,4-beta]PYRIDINES AND IMIDAZO[1,5-beta]PYRIDAZINES AS PDE1 INHIBITORS | H. Lundbeck A/S (DK) | 2020-10-28 | — | — | EP | disclosed |
| CN-111511742-A | Pyrazolo [3,4-b ] pyridines and imidazo [1,5-b ] pyridazines as PDE1 inhibitors | H.隆德贝克有限公司 | 2020-08-07 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210009571-A1 | PYRAZOLO[3,4-B]PYRIDINES AND IMIDAZO[1,5-B]PYRIDAZINES AS PDE1 INHIBITORS | PDE5A, PDE12, PDE3A | PDE1B 8/4885PDE1C 17/4885PDE1A 11/4885 |
| US-11535611-B2 | Pyrazolo[3,4-B]pyridines and imidazo[1,5-B]pyridazines as PDE1 inhibitors | PDE5A, PDE12, PDE3A | PDE1B 8/4885PDE1C 17/4885PDE1A 11/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.