Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE1A | P54750 | 18/20 | 0.48 |
| ▸ | PDE1B | Q01064 | 18/20 | 0.48 |
| ▸ | PDE1C | Q14123 | 18/20 | 0.48 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.39 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22574646 | 0.80 | PDE1A (0.51) | PDE1APDE1BPDE1CALOX5AP | |
| SCHEMBL30672753 | 0.79 | PDE1A (0.53) | PDE1APDE1BPDE1CALOX5AP | |
| SCHEMBL22574700 | 0.79 | PDE1A (0.53) | PDE1APDE1BPDE1CALOX5AP | |
| SCHEMBL22574730 | 0.78 | PDE1A (0.45) | PDE1APDE1BPDE1C | |
| SCHEMBL30672629 | 0.77 | PDE1A (0.48) | PDE1APDE1BPDE1CALOX5AP | |
| SCHEMBL22574654 | 0.77 | PDE1A (0.48) | PDE1APDE1BPDE1CALOX5AP | |
| SCHEMBL31078141 | 0.69 | PDE1B (0.51) | PDE1APDE1BPDE1CALOX5AP | |
| SCHEMBL22574729 | 0.69 | PDE1A (0.46) | PDE1APDE1BPDE1C | |
| SCHEMBL30672661 | 0.69 | PDE1A (0.46) | PDE1APDE1BPDE1C | |
| SCHEMBL29982576 | 0.67 | PDE1A (0.45) | PDE1APDE1BPDE1C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3728250-A1 | PYRAZOLO[3,4-beta]PYRIDINES AND IMIDAZO[1,5-beta]PYRIDAZINES AS PDE1 INHIBITORS | H. Lundbeck A/S (DK) | 2020-10-28 | — | — | EP | disclosed |