Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FLT3 | P36888 | 4/20 | 0.55 |
| ▸ | TYRO3 | Q06418 | 4/20 | 0.55 |
| ▸ | MERTK | Q12866 | 4/20 | 0.55 |
| ▸ | GAS6 | Q14393 | 4/20 | 0.55 |
| ▸ | CDK2 | P24941 | 8/20 | 0.49 |
| ▸ | CCNE1 | P24864 | 5/20 | 0.49 |
| ▸ | MCHR1 | Q99705 | 5/20 | 0.48 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.48 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.48 |
| ▸ | HRH1 | P35367 | 1/20 | 0.48 |
| ▸ | HTR2B | P41595 | 1/20 | 0.48 |
| ▸ | CDK7 | P50613 | 6/20 | 0.46 |
| ▸ | CCNH | P51946 | 6/20 | 0.46 |
| ▸ | MNAT1 | P51948 | 6/20 | 0.46 |
| ▸ | CCNK | O75909 | 3/20 | 0.44 |
| ▸ | CCNA2 | P20248 | 3/20 | 0.44 |
| ▸ | CDK12 | Q9NYV4 | 3/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL559499 | 1.00 | FLT3 (0.55) | FLT3TYRO3MERTKGAS6CDK2 | |
| SCHEMBL558878 | 0.87 | CDK2 (0.54) | CDK2CCNE1MCHR1CDK7CCNH | |
| SCHEMBL2255518 | 0.87 | CDK2 (0.54) | CDK2CCNE1MCHR1CDK7CCNH | |
| SCHEMBL558223 | 0.84 | CDK7 (0.53) | CDK2CCNE1CDK7CCNHMNAT1 | |
| SCHEMBL558222 | 0.84 | CDK7 (0.53) | CDK2CCNE1CDK7CCNHMNAT1 | |
| SCHEMBL2255229 | 0.80 | FLT3 (0.60) | FLT3TYRO3MERTKGAS6CDK2 | |
| SCHEMBL2257569 | 0.80 | MAPK1 (0.46) | FLT3TYRO3MERTKGAS6CDK2 | |
| SCHEMBL559200 | 0.80 | FLT3 (0.60) | FLT3TYRO3MERTKGAS6CDK2 | |
| SCHEMBL558837 | 0.80 | MAPK1 (0.46) | FLT3TYRO3MERTKGAS6CDK2 | |
| SCHEMBL2258872 | 0.80 | CCNE1 (0.47) | TYRO3MERTKGAS6CDK2CCNE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7998978-B2 | Substituted 2-amino-fused heterocyclic compounds | PFIZER INC. (US) | 2011-08-16 | — | — | US | disclosed |
| US-20100056506-A1 | SUBSTITUTED 2-AMINO-FUSED HETEROCYCLIC COMPOUNDS | PFIZER PRODUCTS INC. (US) | 2010-03-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100056506-A1 | SUBSTITUTED 2-AMINO-FUSED HETEROCYCLIC COMPOUNDS | MAPK1, SLC5A1, ATF1 | FLT3 1589/4885TYRO3 691/4885MERTK 2882/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.