Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.47 |
| ▸ | TSHR | P16473 | 2/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | MAPK10 | P53779 | 6/20 | 0.47 |
| ▸ | JUN | P05412 | 2/20 | 0.47 |
| ▸ | USP2 | O75604 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.46 |
| ▸ | MAPK8 | P45983 | 5/20 | 0.42 |
| ▸ | MAPK9 | P45984 | 5/20 | 0.42 |
| ▸ | IRAK4 | Q9NWZ3 | 3/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | IRAK1 | P51617 | 2/20 | 0.39 |
| ▸ | SYK | P43405 | 1/20 | 0.39 |
| ▸ | CDK2 | P24941 | 2/20 | 0.39 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL559434 | 1.00 | KMT2A (0.48) | KMT2AMEN1LMNANPSR1TSHR | |
| SCHEMBL2258186 | 0.83 | MAPK10 (0.50) | MAPK10JUNMAPK8MAPK9IRAK4 | |
| SCHEMBL2258190 | 0.83 | MAPK10 (0.50) | MAPK10JUNMAPK8MAPK9IRAK4 | |
| SCHEMBL558797 | 0.80 | MAPK10 (0.50) | KMT2AMEN1MAPK10JUNMAPK8 | |
| SCHEMBL2259620 | 0.80 | MAPK10 (0.50) | KMT2AMEN1MAPK10JUNMAPK8 | |
| SCHEMBL558248 | 0.80 | MAPK10 (0.58) | KMT2AMEN1MAPK10JUNMAPK8 | |
| SCHEMBL2257727 | 0.80 | MAPK10 (0.58) | KMT2AMEN1MAPK10JUNMAPK8 | |
| SCHEMBL2255188 | 0.79 | MAPK10 (0.49) | MAPK10JUNMAPK8MAPK9IRAK4 | |
| SCHEMBL560268 | 0.79 | MAPK10 (0.49) | MAPK10JUNMAPK8MAPK9IRAK4 | |
| SCHEMBL2259812 | 0.77 | MAPK10 (0.47) | MAPK10JUNMAPK8MAPK9IRAK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7998978-B2 | Substituted 2-amino-fused heterocyclic compounds | PFIZER INC. (US) | 2011-08-16 | — | — | US | disclosed |
| US-20100056506-A1 | SUBSTITUTED 2-AMINO-FUSED HETEROCYCLIC COMPOUNDS | PFIZER PRODUCTS INC. (US) | 2010-03-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100056506-A1 | SUBSTITUTED 2-AMINO-FUSED HETEROCYCLIC COMPOUNDS | MAPK1, SLC5A1, ATF1 | KMT2A 1703/4885MEN1 2633/4885LMNA 3558/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.