Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 3/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 4/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 3/20 | 0.37 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30248383 | 1.00 | MAPT (0.41) | MAPTLMNAPKMSMN1; SMN2NPC1 | |
| SCHEMBL22585510 | 0.91 | MAPT (0.43) | MAPTLMNAPKMSMN1; SMN2NPC1 | |
| SCHEMBL30248509 | 0.91 | MAPT (0.43) | MAPTLMNAPKMSMN1; SMN2NPC1 | |
| SCHEMBL22585498 | 0.91 | MAPT (0.43) | MAPTLMNAPKMSMN1; SMN2NPC1 | |
| SCHEMBL30248563 | 0.90 | MAPT (0.42) | MAPTLMNAPKMSMN1; SMN2NPC1 | |
| SCHEMBL22585735 | 0.90 | MAPT (0.42) | MAPTLMNAPKMSMN1; SMN2NPC1 | |
| SCHEMBL29114895 | 0.90 | MAPT (0.42) | MAPTLMNAPKMSMN1; SMN2NPC1 | |
| SCHEMBL30679687 | 0.90 | MAPT (0.45) | MAPTLMNAPKMSMN1; SMN2NPC1 | |
| SCHEMBL26857507 | 0.90 | MAPT (0.45) | MAPTLMNAPKMSMN1; SMN2NPC1 | |
| SCHEMBL22585489 | 0.89 | MAPT (0.41) | MAPTLMNAPKMSMN1; SMN2NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020215094-A1 | SUBSTITUTED 2-AMINO-PYRAZOLYL-[1,2,4]TRIAZOLO[1,5A] PYRIDINE DERIVATIVES AND USE THEREOF | THE JOHNS HOPKINS UNIVERSITY (US) | 2020-10-22 | — | — | WO | disclosed |