Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 10/20 | 0.74 |
| ▸ | MTOR | P42345 | 4/20 | 0.74 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.74 |
| ▸ | PIK3C2A | O00443 | 1/20 | 0.74 |
| ▸ | PIK3C2B | O00750 | 1/20 | 0.74 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.74 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.74 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.74 |
| ▸ | PRKDC | P78527 | 1/20 | 0.74 |
| ▸ | ATM | Q13315 | 1/20 | 0.74 |
| ▸ | ATR | Q13535 | 1/20 | 0.74 |
| ▸ | RPTOR | Q8N122 | 1/20 | 0.74 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.74 |
| ▸ | MLST8 | Q9BVC4 | 1/20 | 0.74 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.74 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.74 |
| ▸ | BLK | P51451 | 1/20 | 0.51 |
| ▸ | BMX | P51813 | 1/20 | 0.51 |
| ▸ | JAK3 | P52333 | 1/20 | 0.51 |
| ▸ | BTK | Q06187 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22607248 | 0.87 | PIK3CA (0.74) | PIK3CAMTORPIK3CDPIK3C2APIK3C2B | |
| SCHEMBL7919240 | 0.86 | PIK3CA (0.76) | PIK3CAMTORPIK3CDPIK3C2APIK3C2B | |
| SCHEMBL16719231 | 0.86 | PIK3CA (0.73) | PIK3CAMTORPIK3CDPIK3C2APIK3C2B | |
| SCHEMBL16730901 | 0.86 | PIK3CA (0.84) | PIK3CAMTORPIK3CDPIK3C2APIK3C2B | |
| SCHEMBL30214466 | 0.85 | PIK3CA (1.00) | PIK3CAMTORPIK3CDPIK3C2APIK3C2B | |
| SCHEMBL29352777 | 0.85 | PIK3CA (1.00) | PIK3CAMTORPIK3CDPIK3C2APIK3C2B | |
| SCHEMBL6876328 | 0.85 | PIK3CA (1.00) | PIK3CAMTORPIK3CDPIK3C2APIK3C2B | |
| SCHEMBL16719230 | 0.85 | PIK3CA (0.82) | PIK3CAMTORPIK3CDPIK3C2APIK3C2B | |
| SCHEMBL18045499 | 0.85 | PIK3CA (0.82) | PIK3CAMTORPIK3CDPIK3C2APIK3C2B | |
| SCHEMBL16730996 | 0.84 | PIK3CA (0.81) | PIK3CAMTORPIK3CDPIK3C2APIK3C2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220220106-A1 | QUINOLINE COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS AND USES THEREOF | ACADEMY OF MILITARY MEDICAL SCIENCES (CN) | 2022-07-14 | — | — | US | disclosed |
| WO-2020216350-A1 | QUINOLINE COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS AND USES THEREOF | 中国人民解放军军事科学院军事医学研究院 | 2020-10-29 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220220106-A1 | QUINOLINE COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS AND USES THEREOF | MTOR, RICTOR, EIF4E | PIK3CA 58/4885MTOR 1/4885PIK3CD 64/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.