Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.42 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.39 |
| ▸ | CACNB4 | O00305 | 1/20 | 0.39 |
| ▸ | CACNA1A | O00555 | 1/20 | 0.39 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.39 |
| ▸ | CACNG3 | O60359 | 1/20 | 0.39 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.39 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.39 |
| ▸ | CACNB3 | P54284 | 1/20 | 0.39 |
| ▸ | CACNA2D1 | P54289 | 1/20 | 0.39 |
| ▸ | CACNG7 | P62955 | 1/20 | 0.39 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.39 |
| ▸ | CACNA1D | Q01668 | 1/20 | 0.39 |
| ▸ | CACNB1 | Q02641 | 1/20 | 0.39 |
| ▸ | CACNG1 | Q06432 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18999642 | 0.82 | MCL1 (0.43) | HSP90AA1HSP90AB1HPGDKMT2ANOTUM | |
| SCHEMBL19007019 | 0.79 | KLKB1 (0.46) | HPGDLMNAPOLBKMT2ANOTUM | |
| SCHEMBL21967012 | 0.75 | HPGD (0.41) | HPGDLMNAPOLBKMT2ANOTUM | |
| SCHEMBL28490095 | 0.74 | HPGD (0.51) | HPGDPOLBKMT2ATP53MEN1 | |
| SCHEMBL22607086 | 0.74 | MCL1 (0.42) | HSP90AA1HSP90AB1HPGDKMT2ANOTUM | |
| SCHEMBL14602502 | 0.72 | HDAC8 (0.49) | KMT2ANOTUMKDM4ETP53CYP2D6 | |
| SCHEMBL29001267 | 0.71 | MAPK10 (0.51) | HPGDKMT2AKDM4EMEN1 | |
| SCHEMBL266595 | 0.69 | BRD4 (0.56) | HPGDLMNAPOLBKMT2AKDM4E | |
| SCHEMBL11610011 | 0.69 | BRD4 (0.56) | LMNAKMT2ANOTUMCACNA1CMEN1 | |
| SCHEMBL23566142 | 0.69 | TNF (0.41) | HSP90AA1HSP90AB1HPGDPOLBKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3122353-B1 | SUBSTITUTED INDOLE MCL-1 INHIBITORS | UNIV VANDERBILT (US) | 2020-10-28 | — | — | EP | disclosed |