Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H2 | P55055 | 10/20 | 0.73 |
| ▸ | NR1H3 | Q13133 | 9/20 | 0.73 |
| ▸ | RXRA | P19793 | 8/20 | 0.73 |
| ▸ | PTGS2 | P35354 | 10/20 | 0.45 |
| ▸ | PTGS1 | P23219 | 3/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2257370 | 0.89 | NR1H2 (0.65) | NR1H2NR1H3RXRAPTGS2PTGS1 | |
| SCHEMBL12361837 | 0.86 | NR1H2 (0.56) | NR1H2NR1H3RXRAPTGS2PTGS1 | |
| SCHEMBL15453288 | 0.86 | NR1H2 (0.85) | NR1H2NR1H3RXRAPTGS2PTGS1 | |
| SCHEMBL2259525 | 0.85 | NR1H2 (0.68) | NR1H2NR1H3RXRAPTGS2PTGS1 | |
| SCHEMBL12361823 | 0.85 | NR1H2 (0.70) | NR1H2NR1H3RXRAPTGS2PTGS1 | |
| SCHEMBL3582385 | 0.84 | NR1H2 (0.72) | NR1H2NR1H3RXRAPTGS2PTGS1 | |
| SCHEMBL3584533 | 0.84 | NR1H2 (1.00) | NR1H2NR1H3RXRAPTGS2PTGS1 | |
| SCHEMBL3584334 | 0.83 | NR1H2 (0.71) | NR1H2NR1H3RXRAPTGS2PTGS1 | |
| SCHEMBL2259957 | 0.83 | NR1H2 (0.67) | NR1H2NR1H3RXRAPTGS2PTGS1 | |
| SCHEMBL3582872 | 0.83 | NR1H2 (0.82) | NR1H2NR1H3RXRAPTGS2PTGS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2121621-B1 | LXR AND FXR MODULATORS | EXELIXIS PATENT CO LLC (US) | 2014-05-07 | — | — | EP | disclosed |
| US-7998995-B2 | LXR and FXR modulators | EXELIXIS PATENT COMPANY LLC (US) | 2011-08-16 | — | — | US | disclosed |
| US-7998995-B2 | LXR and FXR modulators | EXELIXIS PATENT COMPANY LLC (US) | 2011-08-16 | — | — | US | disclosed |
| US-7998995-B2 | LXR and FXR modulators | EXELIXIS PATENT COMPANY LLC (US) | 2011-08-16 | — | — | US | disclosed |
| US-20100069367-A1 | LXR and FXR Modulators | EXELIXIS, INC. (US) | 2010-03-18 | — | — | US | disclosed |
| US-20100069367-A1 | LXR and FXR Modulators | EXELIXIS, INC. (US) | 2010-03-18 | — | — | US | disclosed |
| US-20100069367-A1 | LXR and FXR Modulators | EXELIXIS, INC. (US) | 2010-03-18 | — | — | US | disclosed |
| EP-2121621-A1 | LXR AND FXR MODULATORS | Exelixis, Inc. (US) | 2009-11-25 | — | — | EP | disclosed |
| WO-2008073825-A1 | LXR AND FXR MODULATORS | EXELIXIS, INC. (US) | 2008-06-19 | — | — | WO | disclosed |
| WO-2008073825-A1 | LXR AND FXR MODULATORS | EXELIXIS, INC. (US) | 2008-06-19 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100069367-A1 | LXR and FXR Modulators | NR1H3, NR1H2, NR1H4 | NR1H2 2/4885NR1H3 1/4885RXRA 8/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.