Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.49 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.39 |
| ▸ | THRB | P10828 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 3/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21069309 | 1.00 | MEN1 (0.49) | MEN1KMT2AKDM4CTHRBHTT | |
| SCHEMBL24574135 | 0.98 | MEN1 (0.48) | MEN1KMT2AKDM4CTHRBHTT | |
| SCHEMBL22787022 | 0.97 | MEN1 (0.50) | MEN1KMT2AKDM4CTHRBHTT | |
| SCHEMBL24574176 | 0.97 | MEN1 (0.47) | MEN1KMT2AKDM4CTHRBHTT | |
| SCHEMBL24574137 | 0.97 | MEN1 (0.47) | MEN1KMT2AKDM4CTHRBHTT | |
| SCHEMBL27269433 | 0.97 | MEN1 (0.50) | MEN1KMT2AKDM4CTHRBHTT | |
| SCHEMBL22070790 | 0.93 | KMT2A (0.49) | MEN1KMT2AKDM4CTSHRL3MBTL1 | |
| SCHEMBL20128999 | 0.93 | KMT2A (0.49) | MEN1KMT2AKDM4CL3MBTL1NPC1 | |
| SCHEMBL578640 | 0.93 | MEN1 (0.43) | MEN1KMT2AKDM4CTHRBHTT | |
| SCHEMBL12286917 | 0.93 | MEN1 (0.43) | MEN1KMT2AKDM4CTHRBHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3731869-A1 | IRAK DEGRADERS AND USES THEREOF | Kymera Therapeutics, Inc. (US) | 2020-11-04 | — | — | EP | disclosed |