Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRBN | Q96SW2 | 15/20 | 0.61 |
| ▸ | DDB1 | Q16531 | 13/20 | 0.61 |
| ▸ | STAT3 | P40763 | 3/20 | 0.56 |
| ▸ | CA2 | P00918 | 2/20 | 0.54 |
| ▸ | DYRK2 | Q92630 | 1/20 | 0.52 |
| ▸ | TNF | P01375 | 1/20 | 0.52 |
| ▸ | IL1B | P01584 | 1/20 | 0.52 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.52 |
| ▸ | IKZF1 | Q13422 | 1/20 | 0.52 |
| ▸ | IKZF3 | Q9UKT9 | 1/20 | 0.52 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.50 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26611506 | 1.00 | CRBN (0.61) | CRBNDDB1STAT3CA2DYRK2 | |
| SCHEMBL31710113 | 0.99 | CRBN (0.62) | CRBNDDB1STAT3CA2DYRK2 | |
| SCHEMBL22609417 | 0.99 | CRBN (0.62) | CRBNDDB1STAT3CA2DYRK2 | |
| SCHEMBL21070053 | 0.91 | CRBN (0.68) | CRBNDDB1STAT3CA2TNF | |
| SCHEMBL23292719 | 0.89 | CRBN (0.66) | CRBNDDB1STAT3TNFIL1B | |
| SCHEMBL21224674 | 0.89 | DDB1 (0.70) | CRBNDDB1STAT3TNFIL1B | |
| SCHEMBL30631253 | 0.88 | CRBN (0.69) | CRBNDDB1STAT3CA2DYRK2 | |
| SCHEMBL21070933 | 0.88 | CRBN (0.69) | CRBNDDB1STAT3CA2DYRK2 | |
| SCHEMBL21070296 | 0.88 | CRBN (0.69) | CRBNDDB1STAT3CA2DYRK2 | |
| SCHEMBL25036530 | 0.88 | CRBN (0.60) | CRBNDDB1STAT3CA2TNF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3731869-A1 | IRAK DEGRADERS AND USES THEREOF | Kymera Therapeutics, Inc. (US) | 2020-11-04 | — | — | EP | disclosed |