Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK4 | P11802 | 5/20 | 0.34 |
| ▸ | CCND1 | P24385 | 3/20 | 0.34 |
| ▸ | CDK2 | P24941 | 11/20 | 0.32 |
| ▸ | CCNA2 | P20248 | 9/20 | 0.32 |
| ▸ | IGF1R | P08069 | 8/20 | 0.32 |
| ▸ | CCNA1 | P78396 | 8/20 | 0.32 |
| ▸ | AURKA | O14965 | 4/20 | 0.32 |
| ▸ | CCND3 | P30281 | 2/20 | 0.32 |
| ▸ | CDK6 | Q00534 | 2/20 | 0.32 |
| ▸ | CCNT1 | O60563 | 2/20 | 0.32 |
| ▸ | CDK1 | P06493 | 2/20 | 0.32 |
| ▸ | CCNB1 | P14635 | 2/20 | 0.32 |
| ▸ | CCNE1 | P24864 | 2/20 | 0.32 |
| ▸ | CDK7 | P50613 | 2/20 | 0.32 |
| ▸ | CDK9 | P50750 | 2/20 | 0.32 |
| ▸ | CCNH | P51946 | 2/20 | 0.32 |
| ▸ | PLK1 | P53350 | 3/20 | 0.31 |
| ▸ | TTK | P33981 | 2/20 | 0.31 |
| ▸ | PLK3 | Q9H4B4 | 2/20 | 0.31 |
| ▸ | PLK2 | Q9NYY3 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22619419 | 0.85 | CDK4 (0.35) | CDK4CCND1CDK2CCNA2IGF1R | |
| SCHEMBL22612188 | 0.82 | KDM4E (0.44) | CDK4CCND1CDK2CCNA2CCNA1 | |
| SCHEMBL22612194 | 0.82 | CDK4 (0.34) | CDK4CCND1CDK2CCNA2IGF1R | |
| SCHEMBL22612617 | 0.72 | CDK2 (0.48) | CDK4CCND1CDK2CCNA2CCNA1 | |
| SCHEMBL22619433 | 0.71 | CDK2 (0.49) | CDK4CCND1CDK2CCNA2IGF1R | |
| SCHEMBL22612198 | 0.69 | CDK2 (0.50) | CDK4CCND1CDK2CCNA2IGF1R | |
| SCHEMBL22619432 | 0.69 | CDK2 (0.49) | CDK4CCND1CDK2CCNA2IGF1R | |
| SCHEMBL22624289 | 0.69 | CDK2 (0.48) | CDK4CCND1CDK2CCNA2CCNA1 | |
| SCHEMBL21663167 | 0.65 | CDK4 (0.50) | CDK4CCND1CDK2CCNA2CCNA1 | |
| SCHEMBL24329228 | 0.60 | KDM4E (0.45) | CDK2CCNA2CCNA1PLK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11447494-B2 | Tricyclic amine compounds as CDK2 inhibitors | INCYTE CORPORATION (US) | 2022-09-20 | — | — | US | disclosed |
| US-11447494-B2 | Tricyclic amine compounds as CDK2 inhibitors | INCYTE CORPORATION (US) | 2022-09-20 | — | — | US | disclosed |
| US-20200347066-A1 | TRICYCLIC AMINE COMPOUNDS AS CDK2 INHIBITORS | INCYTE CORPORATION | 2020-11-05 | — | — | US | disclosed |
| US-20200347066-A1 | TRICYCLIC AMINE COMPOUNDS AS CDK2 INHIBITORS | INCYTE CORPORATION | 2020-11-05 | — | — | US | disclosed |
| WO-2020223558-A1 | TRICYCLIC AMINE COMPOUNDS AS CDK2 INHIBITORS | INCYTE CORPORATION (US) | 2020-11-05 | — | — | WO | disclosed |
| WO-2020223558-A1 | TRICYCLIC AMINE COMPOUNDS AS CDK2 INHIBITORS | INCYTE CORPORATION (US) | 2020-11-05 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11447494-B2 | Tricyclic amine compounds as CDK2 inhibitors | CDK2, CDK1, CCNI | CDK4 12/4885CCND1 47/4885CDK2 1/4885 |
| US-20200347066-A1 | TRICYCLIC AMINE COMPOUNDS AS CDK2 INHIBITORS | CDK2, CDK1, CCNI | CDK4 8/4885CCND1 53/4885CDK2 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.