Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK2 | P24941 | 20/20 | 0.54 |
| ▸ | CCNE1 | P24864 | 3/20 | 0.54 |
| ▸ | CCNA2 | P20248 | 18/20 | 0.43 |
| ▸ | CCNA1 | P78396 | 18/20 | 0.43 |
| ▸ | CDK1 | P06493 | 2/20 | 0.41 |
| ▸ | CCNB1 | P14635 | 2/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | GSK3B | P49841 | 1/20 | 0.41 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.41 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.41 |
| ▸ | AURKA | O14965 | 1/20 | 0.40 |
| ▸ | CDK4 | P11802 | 1/20 | 0.38 |
| ▸ | CCND1 | P24385 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22612611 | 0.84 | CDK2 (0.74) | CDK2CCNE1CCNA2CCNA1CDK1 | |
| SCHEMBL22624418 | 0.77 | CDK2 (0.72) | CDK2CCNE1CCNA2CCNA1CDK1 | |
| SCHEMBL22624421 | 0.75 | IGF1R (0.51) | CDK2CCNE1CCNA2CCNA1CDK1 | |
| SCHEMBL22624402 | 0.75 | CDK2 (0.47) | CDK2CCNE1CCNA2CCNA1CDK1 | |
| SCHEMBL22624325 | 0.75 | CDK2 (0.45) | CDK2CCNE1CCNA2CCNA1CDK1 | |
| SCHEMBL22624382 | 0.73 | IGF1R (0.44) | CDK2CCNE1CCNA2CCNA1CDK1 | |
| SCHEMBL22624397 | 0.71 | CDK2 (0.48) | CDK2CCNE1CCNA2CCNA1CDK1 | |
| SCHEMBL22624393 | 0.71 | CDK2 (0.48) | CDK2CCNE1CCNA2CCNA1CDK1 | |
| SCHEMBL23001261 | 0.70 | CDK2 (0.46) | CDK2CCNE1CDK1CCNB1MAPK1 | |
| SCHEMBL22614910 | 0.68 | CDK2 (0.65) | CDK2CCNE1CCNA2CCNA1CDK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020223469-A1 | N-(1-(METHYLSULFONYL)PIPERIDIN-4-YL)-4,5-DI HYDRO-1H-IMIDAZO[4,5-H]QUINAZOLIN-8-AMINE DERIVATIVES AND RELATED COMPOUNDS AS CYCLIN-DEPENDENT KINASE 2 (CDK2) INHIBITORS FOR TREATING CANCER | INCYTE CORPORATION (US) | 2020-11-05 | — | — | WO | disclosed |