Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPBAR1 | Q8TDU6 | 10/20 | 0.80 |
| ▸ | NR1H4 | Q96RI1 | 6/20 | 0.78 |
| ▸ | SLC10A2 | Q12908 | 4/20 | 0.78 |
| ▸ | ABCB11 | O95342 | 4/20 | 0.78 |
| ▸ | ENPP2 | Q13822 | 4/20 | 0.78 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.78 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.78 |
| ▸ | MEN1 | O00255 | 2/20 | 0.74 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.74 |
| ▸ | SLC10A1 | Q14973 | 2/20 | 0.74 |
| ▸ | LMNA | P02545 | 1/20 | 0.74 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.74 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.74 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.74 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.74 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.74 |
| ▸ | CISD1 | Q9NZ45 | 1/20 | 0.74 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.74 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.74 |
| ▸ | USP2 | O75604 | 1/20 | 0.69 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24224202 | 0.95 | GPBAR1 (0.84) | GPBAR1NR1H4SLC10A2ABCB11ENPP2 | |
| SCHEMBL22608681 | 0.95 | GPBAR1 (0.84) | GPBAR1NR1H4SLC10A2ABCB11ENPP2 | |
| SCHEMBL22608679 | 0.95 | GPBAR1 (0.84) | GPBAR1NR1H4SLC10A2ABCB11ENPP2 | |
| SCHEMBL24404329 | 0.95 | GPBAR1 (0.84) | GPBAR1NR1H4SLC10A2ABCB11ENPP2 | |
| SCHEMBL23345515 | 0.95 | GPBAR1 (0.84) | GPBAR1NR1H4SLC10A2ABCB11ENPP2 | |
| SCHEMBL24404365 | 0.95 | GPBAR1 (0.84) | GPBAR1NR1H4SLC10A2ABCB11ENPP2 | |
| SCHEMBL24404405 | 0.94 | GPBAR1 (0.82) | GPBAR1NR1H4SLC10A2ABCB11ENPP2 | |
| SCHEMBL24224224 | 0.93 | GPBAR1 (0.81) | GPBAR1NR1H4SLC10A2ABCB11ENPP2 | |
| SCHEMBL24404335 | 0.93 | GPBAR1 (0.81) | GPBAR1NR1H4SLC10A2ABCB11ENPP2 | |
| SCHEMBL22626970 | 0.93 | GPBAR1 (0.81) | GPBAR1NR1H4SLC10A2ABCB11ENPP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11833160-B2 | Ursodeoxycholic acid derivatives as HDAC inhibitors for the treatment of polycystic diseases | UNIVERSIDAD DEL PAIS VASCO/EUSKAL HERRIKO UNIBERTSITATEA (ES) | 2023-12-05 | — | — | US | disclosed |
| US-11833160-B2 | Ursodeoxycholic acid derivatives as HDAC inhibitors for the treatment of polycystic diseases | UNIVERSIDAD DEL PAIS VASCO/EUSKAL HERRIKO UNIBERTSITATEA (ES) | 2023-12-05 | — | — | US | disclosed |
| EP-3733684-B9 | URSODEOXYCHOLIC ACID DERIVATIVES FOR THE TREATMENT OF POLYCYSTIC DISEASES | UNIV DEL PAIS VASCO/EUSKAL HERRIKO UNIBERTSITATEA (ES) | 2022-05-11 | — | — | EP | disclosed |
| EP-3733684-B1 | URSODEOXYCHOLIC ACID DERIVATIVES FOR THE TREATMENT OF POLYCYSTIC DISEASES | UNIV DEL PAIS VASCO/EUSKAL HERRIKO UNIBERTSITATEA (ES) | 2022-01-26 | — | — | EP | disclosed |
| US-20210137946-A1 | URSODEOXYCHOLIC ACID DERIVATIVES FOR THE TREATMENT OF POLYCYSTIC DISEASES | FUNDACIO INSTITUT D'INVESTIGACIO BIOMEDICA DE BELLVITGE (IDIBELL) (ES) | 2021-05-13 | — | — | US | disclosed |
| EP-3733684-A1 | URSODEOXYCHOLIC ACID DERIVATIVES FOR THE TREATMENT OF POLYCYSTIC DISEASES | Universidad del País Vasco/Euskal Herriko Unibertsitatea (ES) | 2020-11-04 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210137946-A1 | URSODEOXYCHOLIC ACID DERIVATIVES FOR THE TREATMENT OF POLYCYSTIC DISEASES | PKD1, PKD2, SLC10A1 | GPBAR1 7/4885NR1H4 4/4885SLC10A2 5/4885 |
| US-11833160-B2 | Ursodeoxycholic acid derivatives as HDAC inhibitors for the treatment of polycystic diseases | HDAC1, HDAC2, HDAC9 | GPBAR1 34/4885NR1H4 14/4885SLC10A2 37/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.