Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KAT2B | Q92831 | 1/20 | 0.34 |
| ▸ | LRRK2 | Q5S007 | 5/20 | 0.34 |
| ▸ | NMT1 | P30419 | 1/20 | 0.33 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.33 |
| ▸ | ACACB | O00763 | 2/20 | 0.32 |
| ▸ | HTR6 | P50406 | 1/20 | 0.32 |
| ▸ | CNR1 | P21554 | 1/20 | 0.32 |
| ▸ | CNR2 | P34972 | 1/20 | 0.32 |
| ▸ | DRD2 | P14416 | 1/20 | 0.32 |
| ▸ | DRD3 | P35462 | 1/20 | 0.32 |
| ▸ | TLR9 | Q9NR96 | 2/20 | 0.32 |
| ▸ | TLR8 | Q9NR97 | 2/20 | 0.32 |
| ▸ | TLR7 | Q9NYK1 | 2/20 | 0.32 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21004597 | 0.78 | LRRK2 (0.34) | LRRK2 | |
| SCHEMBL19575426 | 0.76 | LRRK2 (0.47) | LRRK2NMT1 | |
| SCHEMBL19575349 | 0.73 | CNR1 (0.37) | KAT2BHRH3ACACBCNR1CNR2 | |
| SCHEMBL12026440 | 0.72 | HRH3 (0.48) | HRH3 | |
| SCHEMBL19575344 | 0.71 | KAT2B (0.41) | KAT2BHRH3DRD2DRD3 | |
| SCHEMBL10169414 | 0.71 | HRH3 (0.49) | HRH3 | |
| SCHEMBL21004327 | 0.70 | KAT2B (0.38) | KAT2BHRH3CNR1CNR2DRD2 | |
| SCHEMBL19575458 | 0.70 | PARP1 (0.39) | KAT2BHRH3CNR1CNR2 | |
| SCHEMBL21004282 | 0.69 | HRH3 (0.47) | HRH3 | |
| SCHEMBL12026428 | 0.68 | KDM2B (0.37) | KAT2BHRH3DRD2DRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3452465-B1 | SUBSTITUTED 2, 4-DIAMINO-QUINOLINE DERIVATIVES FOR USE IN THE TREATMENT OF PROLIFERATIVE DISEASES | GENOSCIENCE PHARMA (FR) | 2020-11-04 | — | — | EP | disclosed |