Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC1A1 | P43005 | 4/20 | 0.69 |
| ▸ | SLC1A3 | P43003 | 3/20 | 0.69 |
| ▸ | SLC1A2 | P43004 | 3/20 | 0.69 |
| ▸ | GRIK1 | P39086 | 2/20 | 0.59 |
| ▸ | GRIK2 | Q13002 | 1/20 | 0.59 |
| ▸ | GRIK3 | Q13003 | 1/20 | 0.59 |
| ▸ | GRM2 | Q14416 | 2/20 | 0.53 |
| ▸ | GRM3 | Q14832 | 2/20 | 0.53 |
| ▸ | HTR2A | P28223 | 1/20 | 0.51 |
| ▸ | HTR2C | P28335 | 1/20 | 0.51 |
| ▸ | HTR2B | P41595 | 1/20 | 0.51 |
| ▸ | SLC7A11 | Q9UPY5 | 1/20 | 0.48 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.48 |
| ▸ | ALPI | P09923 | 1/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.47 |
| ▸ | XIAP | P98170 | 1/20 | 0.47 |
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.47 |
| ▸ | DPP4 | P27487 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29941480 | 1.00 | SLC1A1 (0.69) | SLC1A1SLC1A3SLC1A2GRIK1GRIK2 | |
| SCHEMBL29401985 | 0.86 | SLC7A5 (0.65) | SLC1A1SLC1A3SLC1A2HTR2AHTR2C | |
| SCHEMBL29584308 | 0.86 | SLC7A5 (0.65) | SLC1A1SLC1A3SLC1A2HTR2AHTR2C | |
| SCHEMBL29554654 | 0.86 | SLC7A5 (0.65) | SLC1A1SLC1A3SLC1A2HTR2AHTR2C | |
| SCHEMBL837890 | 0.86 | SLC7A5 (0.65) | SLC1A1SLC1A3SLC1A2HTR2AHTR2C | |
| SCHEMBL93304 | 0.86 | SLC7A5 (0.65) | SLC1A1SLC1A3SLC1A2HTR2AHTR2C | |
| SCHEMBL93303 | 0.86 | SLC7A5 (0.65) | SLC1A1SLC1A3SLC1A2HTR2AHTR2C | |
| SCHEMBL210104 | 0.86 | SLC7A5 (0.65) | SLC1A1SLC1A3SLC1A2HTR2AHTR2C | |
| SCHEMBL29375097 | 0.86 | SLC7A5 (0.65) | SLC1A1SLC1A3SLC1A2HTR2AHTR2C | |
| SCHEMBL8872177 | 0.86 | CYP1A2 (0.62) | SLC1A1SLC1A3SLC1A2HTR2AHTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8445440-B2 | Dimeric IAP inhibitors | NOVARTIS AG (CH) | 2013-05-21 | — | — | US | disclosed |
| EP-2539333-A1 | DIMERIC IAP INHIBITORS | Novartis AG (CH) | 2013-01-02 | — | — | EP | disclosed |
| WO-2011104266-A1 | DIMERIC IAP INHIBITORS | NOVARTIS AG (CH) | 2011-09-01 | — | — | WO | disclosed |
| US-20110206690-A1 | DIMERIC IAP INHIBITORS | NOVARTIS AG (CH) | 2011-08-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110206690-A1 | DIMERIC IAP INHIBITORS | XIAP, BIRC5, BIRC2 | SLC1A1 4284/4885SLC1A3 4126/4885SLC1A2 4283/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.