Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AR | P10275 | 7/20 | 0.62 |
| ▸ | KCNH2 | Q12809 | 5/20 | 0.62 |
| ▸ | MAPT | P10636 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | XBP1 | P17861 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | DPP4 | P27487 | 3/20 | 0.45 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.45 |
| ▸ | BRD4 | O60885 | 4/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | CA12 | O43570 | 1/20 | 0.38 |
| ▸ | CA1 | P00915 | 1/20 | 0.38 |
| ▸ | CA2 | P00918 | 1/20 | 0.38 |
| ▸ | CA7 | P43166 | 1/20 | 0.38 |
| ▸ | CA9 | Q16790 | 1/20 | 0.38 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12368172 | 1.00 | AR (0.62) | ARKCNH2MAPTALDH1A1XBP1 | |
| SCHEMBL3165102 | 0.88 | AR (0.68) | ARKCNH2MAPTALDH1A1XBP1 | |
| SCHEMBL2264942 | 0.81 | AR (0.64) | ARKCNH2MAPTALDH1A1XBP1 | |
| SCHEMBL2263275 | 0.81 | AR (0.81) | ARKCNH2MAPTALDH1A1XBP1 | |
| SCHEMBL2265255 | 0.80 | AR (0.74) | ARKCNH2MAPTALDH1A1XBP1 | |
| SCHEMBL2267323 | 0.79 | AR (0.70) | ARKCNH2MAPTALDH1A1XBP1 | |
| SCHEMBL2270821 | 0.79 | AR (0.78) | ARKCNH2MAPTALDH1A1XBP1 | |
| SCHEMBL2266723 | 0.78 | AR (0.77) | ARKCNH2MAPTALDH1A1XBP1 | |
| SCHEMBL2266886 | 0.78 | AR (0.70) | ARKCNH2MAPTALDH1A1XBP1 | |
| SCHEMBL2264907 | 0.78 | AR (0.70) | ARKCNH2MAPTALDH1A1XBP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8003649-B2 | Bicyclic derivatives for use in the treatment of androgen receptor associated conditions-155 | ASTRAZENECA AB (SE) | 2011-08-23 | — | — | US | disclosed |
| WO-2009081197-A1 | BICYCLIC DERIVATIVES FOR USE IN THE TREATMENT OF ANDROGEN RECEPTOR ASSOCIATED CONDITIONS | ASTRAZENECA AB (SE) | 2009-07-02 | — | — | WO | disclosed |