Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNT1 | Q5JUK3 | 10/20 | 0.52 |
| ▸ | KCNQ1 | P51787 | 1/20 | 0.47 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.47 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.47 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.47 |
| ▸ | KCNMB1 | Q16558 | 1/20 | 0.47 |
| ▸ | KCNT2 | Q6UVM3 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | ACACB | O00763 | 6/20 | 0.45 |
| ▸ | PPARD | Q03181 | 4/20 | 0.45 |
| ▸ | PPARA | Q07869 | 4/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22637696 | 1.00 | KCNT1 (0.52) | KCNT1KCNQ1KCNH2CACNA1CSCN5A | |
| SCHEMBL22637859 | 0.88 | ACACB (0.55) | KCNT1KCNQ1KCNH2CACNA1CSCN5A | |
| SCHEMBL22637857 | 0.88 | ACACB (0.55) | KCNT1KCNQ1KCNH2CACNA1CSCN5A | |
| SCHEMBL29463427 | 0.87 | KCNT1 (0.51) | KCNT1KCNQ1KCNH2CACNA1CSCN5A | |
| SCHEMBL22637802 | 0.86 | KCNT1 (0.64) | KCNT1KCNQ1KCNH2CACNA1CSCN5A | |
| SCHEMBL22637807 | 0.85 | KCNT1 (0.53) | KCNT1KCNQ1KCNH2CACNA1CSCN5A | |
| SCHEMBL22637806 | 0.85 | KCNT1 (0.53) | KCNT1KCNQ1KCNH2CACNA1CSCN5A | |
| SCHEMBL22637229 | 0.84 | KCNT1 (0.49) | KCNT1TDP1ACACBPPARDPPARA | |
| SCHEMBL22637231 | 0.84 | KCNT1 (0.49) | KCNT1TDP1ACACBPPARDPPARA | |
| SCHEMBL29463522 | 0.81 | KCNT1 (0.81) | KCNT1KCNQ1KCNH2CACNA1CSCN5A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3962481-A1 | KCNT1 INHIBITORS AND METHODS OF USE | Praxis Precision Medicines, Inc. (US) | 2022-03-09 | — | — | EP | disclosed |
| WO-2020227101-A1 | KCNT1 INHIBITORS AND METHODS OF USE | PRAXIS PRECISION MEDICINES, INC. (US) | 2020-11-12 | — | — | WO | disclosed |