Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.44 |
| ▸ | PIM3 | Q86V86 | 5/20 | 0.43 |
| ▸ | PIM2 | Q9P1W9 | 5/20 | 0.43 |
| ▸ | PIM1 | P11309 | 14/20 | 0.41 |
| ▸ | ATR | Q13535 | 1/20 | 0.41 |
| ▸ | PBK | Q96KB5 | 1/20 | 0.39 |
| ▸ | PRKCB | P05771 | 1/20 | 0.39 |
| ▸ | PRKCA | P17252 | 1/20 | 0.39 |
| ▸ | PRKCH | P24723 | 1/20 | 0.39 |
| ▸ | PRKCE | Q02156 | 1/20 | 0.39 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.39 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2264020 | 1.00 | CYP2C19 (0.44) | CYP2C19PIK3CAPIM3PIM2PIM1 | |
| SCHEMBL2263091 | 0.93 | PIM1 (0.44) | CYP2C19PIK3CAPIM3PIM2PIM1 | |
| SCHEMBL2263094 | 0.93 | PIM1 (0.44) | CYP2C19PIK3CAPIM3PIM2PIM1 | |
| SCHEMBL2265574 | 0.91 | PIM1 (0.42) | PIM3PIM2PIM1PBK | |
| SCHEMBL2265568 | 0.91 | PIM1 (0.42) | PIM3PIM2PIM1PBK | |
| SCHEMBL2266901 | 0.88 | PIM1 (0.44) | CYP2C19PIK3CAPIM3PIM2PIM1 | |
| SCHEMBL2266894 | 0.88 | PIM1 (0.44) | CYP2C19PIK3CAPIM3PIM2PIM1 | |
| SCHEMBL2264863 | 0.88 | PIM3 (0.46) | PIM3PIM2PIM1PBK | |
| SCHEMBL2264870 | 0.88 | PIM3 (0.46) | PIM3PIM2PIM1PBK | |
| SCHEMBL13457691 | 0.88 | PIM3 (0.44) | CYP2C19PIK3CAPIM3PIM2PIM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102203075-B | Bicyclic kinase inhibitors | NOVARTIS AG | 2014-09-10 | — | — | CN | claimed |
| US-8735424-B2 | Bicyclic kinase inhibitors | NOVARTIS AG (CH) | 2014-05-27 | — | — | US | claimed |
| US-20110195980-A1 | Bicyclic Kinase Inhibitors | NOVARTIS AG (CH) | 2011-08-11 | — | — | US | claimed |
| CN-102203075-B | Bicyclic kinase inhibitors | NOVARTIS AG | 2014-09-10 | — | — | CN | disclosed |
| US-8735424-B2 | Bicyclic kinase inhibitors | NOVARTIS AG (CH) | 2014-05-27 | — | — | US | disclosed |
| US-8735424-B2 | Bicyclic kinase inhibitors | NOVARTIS AG (CH) | 2014-05-27 | — | — | US | disclosed |
| US-8735424-B2 | Bicyclic kinase inhibitors | NOVARTIS AG (CH) | 2014-05-27 | — | — | US | disclosed |
| US-20110195980-A1 | Bicyclic Kinase Inhibitors | NOVARTIS AG (CH) | 2011-08-11 | — | — | US | disclosed |
| US-20110195980-A1 | Bicyclic Kinase Inhibitors | NOVARTIS AG (CH) | 2011-08-11 | — | — | US | disclosed |
| US-20110195980-A1 | Bicyclic Kinase Inhibitors | NOVARTIS AG (CH) | 2011-08-11 | — | — | US | disclosed |
| WO-2010026121-A1 | BICYCLIC KINASE INHIBITORS | NOVARTIS AG (CH) | 2010-03-11 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110195980-A1 | Bicyclic Kinase Inhibitors | PIM1, PIM2, PIM3 | CYP2C19 3920/4885PIK3CA 64/4885PIM3 3/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.