Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLK4 | O00444 | 1/20 | 0.80 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.80 |
| ▸ | AURKA | O14965 | 1/20 | 0.80 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.80 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.80 |
| ▸ | CSF1R | P07333 | 1/20 | 0.80 |
| ▸ | RET | P07949 | 1/20 | 0.80 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.80 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.80 |
| ▸ | LTK | P29376 | 1/20 | 0.80 |
| ▸ | KDR | P35968 | 1/20 | 0.80 |
| ▸ | MAP2K2 | P36507 | 1/20 | 0.80 |
| ▸ | FLT3 | P36888 | 1/20 | 0.80 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.80 |
| ▸ | PRKX | P51817 | 1/20 | 0.80 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.80 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.80 |
| ▸ | MST1R | Q04912 | 1/20 | 0.80 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.80 |
| ▸ | BTK | Q06187 | 1/20 | 0.80 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29696521 | 0.89 | PLK4 (1.00) | PLK4CHEK1AURKADAPK3MAP4K4 | |
| SCHEMBL2264295 | 0.89 | PLK4 (1.00) | PLK4CHEK1AURKADAPK3MAP4K4 | |
| Oxalic Acid SCHEMBL28217953 | 0.88 | PLK4 (0.90) | PLK4CHEK1AURKADAPK3MAP4K4 | |
| Fumaric Acid SCHEMBL16827089 | 0.84 | PLK4 (0.82) | PLK4CHEK1AURKADAPK3MAP4K4 | |
| Fumaric Acid SCHEMBL16827083 | 0.84 | PLK4 (0.82) | PLK4CHEK1AURKADAPK3MAP4K4 | |
| SCHEMBL259689 | 0.78 | PLK4 (0.72) | PLK4CHEK1AURKADAPK3MAP4K4 | |
| SCHEMBL29520722 | 0.78 | PLK4 (0.72) | PLK4CHEK1AURKADAPK3MAP4K4 | |
| Trifluoroacetic Acid SCHEMBL29782684 | 0.77 | PDPK1 (0.79) | PLK4CHEK1AURKADAPK3MAP4K4 | |
| Trifluoroacetic Acid SCHEMBL27734073 | 0.77 | PDPK1 (0.79) | PLK4CHEK1AURKADAPK3MAP4K4 | |
| Trifluoroacetic Acid SCHEMBL4590414 | 0.77 | PDPK1 (0.79) | PLK4CHEK1AURKADAPK3MAP4K4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110201657-A1 | AMIDE SUBSTITUTED INDAZOLE AND BENZOTRIAZOLE DERIVATIVES AS POLY(ADP-RIBOSE)POLYMERASE (PARP) INHIBITORS | ISTITUTO DI RICERCHE DI BIOLOGIA MOLECOLARE P. ANGELETTI SPA (IT) | 2011-08-18 | — | — | US | disclosed |
| US-20090275619-A1 | Amide Substituted Indazole and Benzotriazole Derivatives as Poly(ADP-Ribose)Polymerase (PARP) Inhibitors | ISTITUTO DI RICERCHE DI BIOLOGIA MOLECOLARE P. ANGELETTI SPA (IT) | 2009-11-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090275619-A1 | Amide Substituted Indazole and Benzotriazole Derivatives as Poly(ADP-Ribose)Polymerase (PARP) Inhibitors | PARP1, PARP3, PARP2 | PLK4 309/4885CHEK1 43/4885AURKA 804/4885 |
| US-20110201657-A1 | AMIDE SUBSTITUTED INDAZOLE AND BENZOTRIAZOLE DERIVATIVES AS POLY(ADP-RIBOSE)POLYMERASE (PARP) INHIBITORS | PARP1, PARP3, PARP2 | PLK4 309/4885CHEK1 43/4885AURKA 804/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.