Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PREP | P48147 | 2/20 | 0.40 |
| ▸ | DPP4 | P27487 | 1/20 | 0.37 |
| ▸ | CTSC | P53634 | 10/20 | 0.36 |
| ▸ | CTSK | P43235 | 4/20 | 0.36 |
| ▸ | HTRA1 | Q92743 | 1/20 | 0.35 |
| ▸ | MC4R | P32245 | 1/20 | 0.34 |
| ▸ | MC5R | P33032 | 1/20 | 0.34 |
| ▸ | XIAP | P98170 | 1/20 | 0.34 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.33 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16064022 | 1.00 | PREP (0.40) | PREPDPP4CTSCCTSKHTRA1 | |
| SCHEMBL20384053 | 1.00 | PREP (0.40) | PREPDPP4CTSCCTSKHTRA1 | |
| SCHEMBL22643295 | 0.96 | PREP (0.40) | PREPDPP4CTSCCTSKHTRA1 | |
| SCHEMBL16064057 | 0.96 | PREP (0.40) | PREPDPP4CTSCCTSKHTRA1 | |
| SCHEMBL20384089 | 0.93 | PREP (0.38) | PREPDPP4CTSCCTSKHTRA1 | |
| SCHEMBL17483614 | 0.93 | PREP (0.38) | PREPDPP4CTSCCTSKHTRA1 | |
| SCHEMBL21076252 | 0.88 | PREP (0.38) | PREPDPP4CTSCCTSKHTRA1 | |
| SCHEMBL22643208 | 0.88 | CTSC (0.47) | PREPDPP4CTSCCTSKHTRA1 | |
| SCHEMBL16064455 | 0.88 | CTSC (0.48) | PREPDPP4CTSCCTSKHTRA1 | |
| SCHEMBL16064234 | 0.88 | CTSC (0.47) | PREPDPP4CTSCCTSKHTRA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2970283-B1 | SUBSTITUTED 2-AZA-BICYCLO[2.2.1]HEPTANE-3-CARBOXYLIC ACID (BENZYL-CYANO-METHYL)-AMIDES INHIBITORS OF CATHEPSIN C | BOEHRINGER INGELHEIM INT (DE) | 2020-11-11 | — | — | EP | disclosed |