Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSC | P53634 | 4/20 | 0.42 |
| ▸ | PREP | P48147 | 3/20 | 0.38 |
| ▸ | F11 | P03951 | 1/20 | 0.33 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.32 |
| ▸ | NAMPT | P43490 | 2/20 | 0.32 |
| ▸ | JAK1 | P23458 | 1/20 | 0.32 |
| ▸ | ABL1 | P00519 | 1/20 | 0.31 |
| ▸ | IDO1 | P14902 | 1/20 | 0.31 |
| ▸ | TDO2 | P48775 | 1/20 | 0.31 |
| ▸ | HTRA1 | Q92743 | 1/20 | 0.31 |
| ▸ | ACACB | O00763 | 1/20 | 0.30 |
| ▸ | ELANE | P08246 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19155235 | 1.00 | CTSC (0.42) | CTSCPREPF11ROCK2NAMPT | |
| SCHEMBL19155078 | 1.00 | CTSC (0.42) | CTSCPREPF11ROCK2NAMPT | |
| SCHEMBL17620407 | 0.86 | CTSC (0.59) | CTSCPREP | |
| SCHEMBL16064377 | 0.86 | CTSC (0.59) | CTSCPREP | |
| SCHEMBL16064209 | 0.86 | CTSC (0.43) | CTSCPREPF11ROCK2NAMPT | |
| SCHEMBL15081640 | 0.80 | CTSC (0.61) | CTSC | |
| SCHEMBL16064090 | 0.80 | CTSC (0.59) | CTSCPREP | |
| SCHEMBL16064089 | 0.80 | CTSC (0.43) | CTSCPREPF11ROCK2HTRA1 | |
| SCHEMBL18828790 | 0.78 | PREP (0.41) | PREPHTRA1ELANE | |
| SCHEMBL19368355 | 0.76 | CTSC (0.70) | CTSC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2970283-B1 | SUBSTITUTED 2-AZA-BICYCLO[2.2.1]HEPTANE-3-CARBOXYLIC ACID (BENZYL-CYANO-METHYL)-AMIDES INHIBITORS OF CATHEPSIN C | BOEHRINGER INGELHEIM INT (DE) | 2020-11-11 | — | — | EP | disclosed |