Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 18/20 | 0.58 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.48 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.48 |
| ▸ | GRIN2B | Q13224 | 4/20 | 0.46 |
| ▸ | ACHE | P22303 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19998601 | 0.84 | KCNH2 (0.62) | KCNH2PRMT5WDR77GRIN2B | |
| SCHEMBL22642969 | 0.81 | KCNH2 (0.63) | KCNH2PRMT5WDR77GRIN2B | |
| SCHEMBL16911740 | 0.80 | PRMT5 (0.48) | KCNH2PRMT5WDR77ACHE | |
| SCHEMBL17130593 | 0.80 | PRMT5 (0.48) | KCNH2PRMT5WDR77ACHE | |
| SCHEMBL16812740 | 0.80 | KCNH2 (0.46) | KCNH2PRMT5WDR77GRIN2B | |
| SCHEMBL10094700 | 0.79 | PDK2 (0.45) | PRMT5WDR77ACHE | |
| Hydrochloric Acid SCHEMBL16648539 | 0.79 | KCNH2 (0.46) | KCNH2PRMT5WDR77GRIN2B | |
| SCHEMBL17795050 | 0.79 | NAMPT (0.48) | KCNH2PRMT5WDR77GRIN2BACHE | |
| SCHEMBL16911242 | 0.78 | PRMT5 (0.46) | KCNH2PRMT5WDR77GRIN2BACHE | |
| SCHEMBL19998585 | 0.78 | KCNH2 (0.59) | KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2970283-B1 | SUBSTITUTED 2-AZA-BICYCLO[2.2.1]HEPTANE-3-CARBOXYLIC ACID (BENZYL-CYANO-METHYL)-AMIDES INHIBITORS OF CATHEPSIN C | BOEHRINGER INGELHEIM INT (DE) | 2020-11-11 | — | — | EP | disclosed |