Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 13/20 | 0.63 |
| ▸ | MAPK13 | O15264 | 5/20 | 0.63 |
| ▸ | ABL1 | P00519 | 2/20 | 0.61 |
| ▸ | BRAF | P15056 | 4/20 | 0.55 |
| ▸ | RAF1 | P04049 | 2/20 | 0.46 |
| ▸ | RIPK1 | Q13546 | 2/20 | 0.46 |
| ▸ | CSF1R | P07333 | 2/20 | 0.46 |
| ▸ | MET | P08581 | 2/20 | 0.46 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.46 |
| ▸ | KDR | P35968 | 2/20 | 0.46 |
| ▸ | FLT3 | P36888 | 2/20 | 0.46 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.46 |
| ▸ | PLK4 | O00444 | 1/20 | 0.45 |
| ▸ | ACOX3 | O15254 | 1/20 | 0.45 |
| ▸ | MAP3K7 | O43318 | 1/20 | 0.45 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.45 |
| ▸ | JAK2 | O60674 | 1/20 | 0.45 |
| ▸ | ERN1 | O75460 | 1/20 | 0.45 |
| ▸ | RPS6KA4 | O75676 | 1/20 | 0.45 |
| ▸ | STK10 | O94804 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL828109 | 0.92 | MAPK14 (0.54) | MAPK14MAPK13ABL1BRAFCSF1R | |
| SCHEMBL827920 | 0.92 | MAPK14 (0.65) | MAPK14MAPK13ABL1BRAFRAF1 | |
| SCHEMBL574511 | 0.92 | MAPK14 (0.65) | MAPK14MAPK13ABL1BRAFRAF1 | |
| SCHEMBL574179 | 0.90 | MAPK14 (0.63) | MAPK14MAPK13ABL1BRAFRAF1 | |
| SCHEMBL574586 | 0.89 | MAPK14 (0.62) | MAPK14MAPK13ABL1BRAFRAF1 | |
| SCHEMBL573294 | 0.89 | MAPK14 (0.69) | MAPK14MAPK13ABL1BRAFRAF1 | |
| SCHEMBL574472 | 0.87 | MAPK14 (0.59) | MAPK14MAPK13ABL1BRAFKDR | |
| SCHEMBL574510 | 0.86 | MAPK14 (0.61) | MAPK14MAPK13ABL1RAF1CSF1R | |
| SCHEMBL573781 | 0.84 | KDR (0.52) | MAPK14MAPK13ABL1BRAFCSF1R | |
| SCHEMBL828556 | 0.84 | KDR (0.46) | MAPK14MAPK13ABL1BRAFCSF1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110189167-A1 | Methods and Compositions for the Treatment of Myeloproliferative Diseases and other Proliferative Diseases | DECIPHERA PHARMACEUTICALS, LLC | 2011-08-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110189167-A1 | Methods and Compositions for the Treatment of Myeloproliferative Diseases and other Proliferative Diseases | MCL1, NRAS, ABL1 | MAPK14 207/4885MAPK13 290/4885ABL1 3/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.