SCHEMBL22645595

SCHEMBL22645595

COc1cc(C)[nH]c(=O)c1CN1CCn2ccc3cc(-c4c(C)nn(C)c4C)c(Cl)c(c32)C1=O

nearest known ligand 0.75

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
EZH2 Q15910 20/20 0.75
EZH1 Q92800 2/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29840725 1.00 EZH2 (0.75) EZH2EZH1
SCHEMBL29840649 0.90 EZH2 (0.70) EZH2EZH1
SCHEMBL22645600 0.90 EZH2 (0.70) EZH2EZH1
SCHEMBL22645593 0.89 EZH2 (0.70) EZH2EZH1
SCHEMBL29840788 0.89 EZH2 (0.70) EZH2EZH1
SCHEMBL22645641 0.86 EZH2 (1.00) EZH2
SCHEMBL29840832 0.86 EZH2 (1.00) EZH2
SCHEMBL22645592 0.86 EZH2 (0.71) EZH2EZH1
SCHEMBL29840834 0.86 EZH2 (0.71) EZH2EZH1
SCHEMBL22645621 0.79 EZH2 (0.88) EZH2EZH1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2020224607-A1 EZH2 INHIBITOR AND USE THEREOF 南京药石科技股份有限公司 2020-11-12 WO disclosed