Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 8/20 | 0.57 |
| ▸ | PDE4D | Q08499 | 4/20 | 0.54 |
| ▸ | NR1H4 | Q96RI1 | 2/20 | 0.54 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.49 |
| ▸ | CNR1 | P21554 | 1/20 | 0.49 |
| ▸ | PLK1 | P53350 | 1/20 | 0.47 |
| ▸ | KMO | O15229 | 2/20 | 0.46 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.46 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.45 |
| ▸ | SYK | P43405 | 1/20 | 0.45 |
| ▸ | AURKA | O14965 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15947841 | 0.90 | PDE4B (0.57) | PDE4BPDE4DCYP3A4CYP2C19CNR1 | |
| Hydrochloric Acid SCHEMBL15660264 | 0.89 | PDE4B (0.56) | PDE4BPDE4DCYP3A4CYP2C19CNR1 | |
| SCHEMBL15948056 | 0.83 | PDE4B (0.55) | PDE4BCNR1PLK1TGFBR1 | |
| Hydrochloric Acid SCHEMBL15659111 | 0.82 | PDE4B (0.54) | PDE4BCNR1PLK1TGFBR1 | |
| SCHEMBL539095 | 0.75 | PDE4B (0.54) | PDE4BPDE4DNR1H4CYP3A4CYP2C19 | |
| SCHEMBL4201881 | 0.74 | ABCC4 (0.67) | PDE4BPDE4DNR1H4CYP3A4CYP2C19 | |
| SCHEMBL15661342 | 0.73 | PDE4B (0.63) | PDE4BPDE4DNR1H4CYP3A4CYP2C19 | |
| SCHEMBL15658015 | 0.73 | PDE4B (1.00) | PDE4BPDE4DNR1H4CYP3A4CYP2C19 | |
| SCHEMBL26341803 | 0.72 | PDE4B (0.61) | PDE4BPDE4DCYP3A4CYP2C19 | |
| SCHEMBL15661353 | 0.72 | PDE4B (0.60) | PDE4BPDE4DCYP3A4CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20200354384-A1 | HETEROARYL INHIBITORS OF PDE4 | Tetra Discovery Partners, LLC | 2020-11-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200354384-A1 | HETEROARYL INHIBITORS OF PDE4 | PDE4A, PDE4B, PDE4C | PDE4B 2/4885PDE4D 9/4885NR1H4 341/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.