Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRN | P28799 | 6/20 | 0.64 |
| ▸ | SORT1 | Q99523 | 6/20 | 0.64 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.64 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | CA12 | O43570 | 1/20 | 0.34 |
| ▸ | CA1 | P00915 | 1/20 | 0.34 |
| ▸ | CA2 | P00918 | 1/20 | 0.34 |
| ▸ | CA9 | Q16790 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | CTSL | P07711 | 2/20 | 0.33 |
| ▸ | NPC1 | O15118 | 2/20 | 0.33 |
| ▸ | KLKB1 | P03952 | 2/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22649482 | 0.86 | GRN (0.61) | GRNSORT1KDM4EMAPTCA12 | |
| Hydrochloric Acid SCHEMBL8932269 | 0.82 | GRN (0.69) | GRNSORT1KDM4EALDH1A1CYP3A4 | |
| SCHEMBL17920 | 0.80 | GRN (0.71) | GRNSORT1KDM4EALDH1A1CYP3A4 | |
| Hydrochloric Acid SCHEMBL8760885 | 0.80 | GRN (0.96) | GRNSORT1KDM4EMAPTCTSL | |
| SCHEMBL1572486 | 0.79 | GRN (1.00) | GRNSORT1KDM4EMAPTCTSL | |
| SCHEMBL2355530 | 0.78 | GRN (0.67) | GRNSORT1KDM4EMAPTCA12 | |
| SCHEMBL26250857 | 0.78 | GRN (0.67) | GRNSORT1KDM4EMAPTCA12 | |
| SCHEMBL22649287 | 0.77 | GRN (0.61) | GRNSORT1KDM4EMAPTCA12 | |
| SCHEMBL22649285 | 0.76 | GRN (0.54) | GRNSORT1KDM4EMAPTALDH1A1 | |
| SCHEMBL10203508 | 0.76 | GRN (0.54) | GRNSORT1KDM4EMAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020227101-A1 | KCNT1 INHIBITORS AND METHODS OF USE | PRAXIS PRECISION MEDICINES, INC. (US) | 2020-11-12 | — | — | WO | disclosed |