SCHEMBL22650579

SCHEMBL22650579

CC(C)n1cnc2c(F)nc(-c3ccnc(Nc4ccc(N5CCNCC5=O)cn4)n3)cc21

nearest known ligand 0.48

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
CDK4 P11802 16/20 0.48
CDK6 Q00534 10/20 0.48
CCND1 P24385 14/20 0.44
CDK1 P06493 6/20 0.44
CCNA2 P20248 6/20 0.44
CCNB1 P14635 5/20 0.44
CDK2 P24941 5/20 0.44
CCNA1 P78396 3/20 0.44
CCND3 P30281 5/20 0.41
CCNT1 O60563 3/20 0.41
CDK7 P50613 3/20 0.41
CDK9 P50750 3/20 0.41
CCNH P51946 3/20 0.41
MNAT1 P51948 1/20 0.41
CDK5 Q00535 1/20 0.41
CDK5R1 Q15078 1/20 0.41
MAP4K1 Q92918 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL22650778 0.88 CDK4 (0.42) CDK4CDK6CCND1CDK1CCNA2
SCHEMBL22650628 0.87 CDK4 (0.58) CDK4CDK6CCND1CDK1CCNA2
SCHEMBL22650780 0.87 CDK4 (0.54) CDK4CDK6CCND1CDK1CCNA2
SCHEMBL22650875 0.86 TYK2 (0.44) CDK4CDK6CCND1CDK1CCNA2
SCHEMBL22650576 0.86 CDK6 (0.38) CDK4CDK6CCND1CDK1CCNA2
SCHEMBL22650574 0.84 CDK4 (0.43) CDK4CDK6CCND1CDK1CCNA2
SCHEMBL22650776 0.82 CDK4 (0.36) CDK4CDK6CCND1CDK1CCNA2
SCHEMBL22650607 0.82 CDK4 (0.46) CDK4CDK6CCND1CDK1CCNA2
SCHEMBL22650622 0.82 CDK4 (0.52) CDK4CDK6CCND1CDK1CCNA2
SCHEMBL22650619 0.81 CDK4 (0.40) CDK4CDK6CCND1CDK1CCNA2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2020224568-A1 CDK INHIBITORS QILU REGOR THERAPEUTICS INC. (CN) 2020-11-12 WO disclosed