SCHEMBL22650760 — predicted protein targets

Predicted protein targets (top 15)

	gene	UniProt	supporting neighbours	confidence
▸	CDK4	P11802	18/20	0.39

▸	CCND1	P24385	13/20	0.39

▸	CDK6	Q00534	12/20	0.39

▸	CDK1	P06493	10/20	0.39

▸	CCNB1	P14635	8/20	0.39

▸	CCND3	P30281	8/20	0.38

▸	CCNA2	P20248	10/20	0.36

▸	CDK2	P24941	9/20	0.35

▸	CCNA1	P78396	6/20	0.35

▸	GSK3B	P49841	1/20	0.34

▸	CDK7	P50613	2/20	0.33

▸	CCNH	P51946	2/20	0.33

▸	CCNE1	P24864	1/20	0.33

▸	CCNT1	O60563	1/20	0.33

▸	CDK9	P50750	1/20	0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
SCHEMBL22650457	0.92	CDK4 (0.40)	CDK4CCND1CDK6CDK1CCNB1
SCHEMBL22650434	0.92	JAK2 (0.36)	CDK4CCND1CDK1CCNB1CDK2
SCHEMBL22650837	0.90	CDK4 (0.41)	CDK4CCND1CDK6CDK1CCNB1
SCHEMBL29491156	0.90	CDK4 (0.41)	CDK4CCND1CDK6CDK1CCNB1
SCHEMBL22650835	0.90	CDK4 (0.41)	CDK4CCND1CDK6CDK1CCNB1
SCHEMBL22650838	0.90	CDK4 (0.41)	CDK4CCND1CDK6CDK1CCNB1
SCHEMBL22650418	0.87	CDK4 (0.39)	CDK4CCND1CDK6CDK1CCNB1
SCHEMBL22650453	0.87	CDK4 (0.42)	CDK4CCND1CDK6CDK1CCNB1
SCHEMBL22650594	0.87	CDK4 (0.42)	CDK4CCND1CDK6CDK1CCNB1
SCHEMBL22650420	0.86	CDK4 (0.40)	CDK4CCND1CDK6CDK1CCNB1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
WO-2020224568-A1	CDK INHIBITORS	QILU REGOR THERAPEUTICS INC. (CN)	2020-11-12	—	—	WO	disclosed