SCHEMBL22650944

SCHEMBL22650944

CC(C)c1cnn2ccc(-c3nc(NC4CCN(S(C)(=O)=O)CC4)ncc3F)cc12

nearest known ligand 0.61

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
CDK2 P24941 11/20 0.61
CCNE1 P24864 10/20 0.61
CDK1 P06493 8/20 0.61
CCNB1 P14635 7/20 0.61
CCNB2 O95067 2/20 0.61
CCNE2 O96020 2/20 0.61
CDK5 Q00535 2/20 0.61
CDK5R1 Q15078 2/20 0.61
CCNB3 Q8WWL7 2/20 0.61
CDK6 Q00534 12/20 0.49
CDK4 P11802 12/20 0.49
CCND1 P24385 12/20 0.49
CCND3 P30281 11/20 0.49
CCNT1 O60563 1/20 0.47
CDK9 P50750 1/20 0.47
P2RX3 P56373 1/20 0.44
P2RX2 Q9UBL9 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL22650593 0.77 CDK6 (0.46) CDK2CCNE1CDK1CCNB1CDK5
SCHEMBL22650482 0.77 CDK1 (0.59) CDK2CCNE1CDK1CCNB1CCNB2
SCHEMBL24619185 0.77 CCNE1 (0.59) CDK2CCNE1CDK1CCNB1CCNB2
SCHEMBL29727059 0.77 CCNE1 (0.59) CDK2CCNE1CDK1CCNB1CCNB2
SCHEMBL29233646 0.77 CDK2 (0.66) CDK2CCNE1CDK1CCNB1CCNB2
SCHEMBL31472288 0.77 CDK2 (0.66) CDK2CCNE1CDK1CCNB1CCNB2
SCHEMBL22650718 0.76 CDK6 (0.44) CDK2CCNE1CDK1CCNB1CDK5
SCHEMBL22650852 0.76 CDK2 (0.59) CDK2CCNE1CDK1CCNB1CCNB2
SCHEMBL29212023 0.75 CCNE1 (0.67) CDK2CCNE1CDK1CCNB1CCNB2
SCHEMBL30838831 0.75 CDK2 (0.64) CDK2CCNE1CDK1CCNB1CCNB2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2020224568-A1 CDK INHIBITORS QILU REGOR THERAPEUTICS INC. (CN) 2020-11-12 WO disclosed