Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAF1 | P04049 | 13/20 | 0.49 |
| ▸ | BRAF | P15056 | 5/20 | 0.39 |
| ▸ | ABL1 | P00519 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22612720 | 0.88 | RAF1 (0.62) | RAF1BRAFABL1 | |
| SCHEMBL30439610 | 0.88 | RAF1 (0.62) | RAF1BRAFABL1 | |
| SCHEMBL22625553 | 0.78 | RAF1 (0.75) | RAF1BRAFABL1 | |
| SCHEMBL22625547 | 0.78 | RAF1 (0.75) | RAF1BRAFABL1 | |
| SCHEMBL22612716 | 0.77 | RAF1 (0.61) | RAF1BRAFABL1 | |
| SCHEMBL22652917 | 0.75 | RAF1 (0.56) | RAF1BRAF | |
| SCHEMBL30439599 | 0.75 | RAF1 (0.62) | RAF1BRAF | |
| SCHEMBL22612762 | 0.75 | RAF1 (0.62) | RAF1BRAF | |
| SCHEMBL29071314 | 0.72 | RAF1 (0.51) | RAF1 | |
| SCHEMBL22625527 | 0.69 | RAF1 (0.53) | RAF1BRAFABL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020227020-A1 | INHIBITORS OF RAF KINASES | KINNATE BIOPHARMA INC. (US) | 2020-11-12 | — | — | WO | disclosed |