Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTK2 | Q05397 | 15/20 | 0.81 |
| ▸ | PLK1 | P53350 | 1/20 | 0.81 |
| ▸ | LRRK2 | Q5S007 | 5/20 | 0.72 |
| ▸ | MAPK7 | Q13164 | 4/20 | 0.72 |
| ▸ | DCLK1 | O15075 | 4/20 | 0.68 |
| ▸ | GAK | O14976 | 1/20 | 0.61 |
| ▸ | BRD4 | O60885 | 1/20 | 0.61 |
| ▸ | TNK2 | Q07912 | 1/20 | 0.61 |
| ▸ | TNK1 | Q13470 | 1/20 | 0.61 |
| ▸ | DCLK2 | Q8N568 | 1/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29517467 | 1.00 | PTK2 (0.81) | PTK2PLK1LRRK2MAPK7DCLK1 | |
| SCHEMBL29767861 | 0.90 | PTK2 (1.00) | PTK2PLK1LRRK2MAPK7 | |
| SCHEMBL29517502 | 0.88 | PTK2 (1.00) | PTK2PLK1LRRK2MAPK7DCLK1 | |
| SCHEMBL29517755 | 0.88 | PTK2 (1.00) | PTK2PLK1LRRK2MAPK7DCLK1 | |
| SCHEMBL22658904 | 0.87 | PTK2 (1.00) | PTK2PLK1LRRK2MAPK7DCLK1 | |
| SCHEMBL29517547 | 0.87 | PTK2 (1.00) | PTK2PLK1LRRK2MAPK7DCLK1 | |
| SCHEMBL22658775 | 0.87 | PTK2 (0.94) | PTK2PLK1LRRK2DCLK1 | |
| SCHEMBL29517311 | 0.87 | PTK2 (0.94) | PTK2PLK1LRRK2DCLK1 | |
| SCHEMBL616301 | 0.84 | LRRK2 (1.00) | PTK2PLK1LRRK2MAPK7DCLK1 | |
| SCHEMBL29517325 | 0.83 | PTK2 (1.00) | PTK2PLK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020231726-A1 | SMALL-MOLECULE FOCAL ADHESION KINASE (FAK) INHIBITORS | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2020-11-19 | — | — | WO | disclosed |