Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 4/20 | 0.56 |
| ▸ | RAB9A | P51151 | 4/20 | 0.56 |
| ▸ | CASP3 | P42574 | 1/20 | 0.56 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.56 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.56 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.56 |
| ▸ | EGFR | P00533 | 3/20 | 0.56 |
| ▸ | MAOB | P27338 | 1/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.55 |
| ▸ | GAA | P10253 | 1/20 | 0.55 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.55 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.55 |
| ▸ | NR4A3 | Q92570 | 1/20 | 0.55 |
| ▸ | HTT | P42858 | 3/20 | 0.53 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.53 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.52 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.52 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22664709 | 0.99 | EGFR (0.58) | NPC1RAB9ACASP3SENP8SENP7 | |
| SCHEMBL22664705 | 0.89 | EGFR (0.58) | EGFRMAOBALDH1A1GAANR4A1 | |
| SCHEMBL10982882 | 0.88 | CHRM4 (0.53) | EGFRMAOBNR4A1NR4A2NR4A3 | |
| SCHEMBL10734821 | 0.86 | GRIN2B (0.64) | MAOBHRH3SMN1; SMN2CHRM4 | |
| SCHEMBL6152148 | 0.85 | GRIN2B (0.50) | EGFRMAOBNR4A1NR4A2NR4A3 | |
| SCHEMBL6151725 | 0.85 | GRIN2B (0.50) | EGFRMAOBNR4A1NR4A2NR4A3 | |
| SCHEMBL9131979 | 0.85 | GRIN2B (0.55) | NPC1RAB9ACASP3SENP8SENP7 | |
| SCHEMBL7331271 | 0.85 | GRIN2B (0.55) | NPC1RAB9ACASP3SENP8SENP7 | |
| SCHEMBL6690779 | 0.85 | GRIN2B (0.50) | EGFRMAOBNR4A1NR4A2NR4A3 | |
| SCHEMBL6899603 | 0.82 | CHRM4 (0.51) | EGFRMAOBKDM4ENR4A1NR4A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110627704-B | Preparation method of bazedoxifene | 艾瑞吉瑞股份公司 | 2024-02-23 | — | — | CN | disclosed |
| US-10844047-B2 | Process for the preparation of bazedoxifene | ERREGIERRE S.P.A. (IT) | 2020-11-24 | — | — | US | disclosed |
| CN-110627704-A | Preparation method of bazedoxifene | 艾瑞吉瑞股份公司 | 2019-12-31 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10844047-B2 | Process for the preparation of bazedoxifene | CYP19A1, CYP3A5, CYP4A11 | NPC1 2730/4885RAB9A 2773/4885CASP3 2660/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.