Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.66 |
| ▸ | IDO1 | P14902 | 1/20 | 0.66 |
| ▸ | CDK2 | P24941 | 1/20 | 0.66 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.58 |
| ▸ | CTNNB1 | P35222 | 3/20 | 0.47 |
| ▸ | WNT3A | P56704 | 3/20 | 0.47 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.47 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.47 |
| ▸ | RAB9A | P51151 | 5/20 | 0.46 |
| ▸ | NPC1 | O15118 | 4/20 | 0.46 |
| ▸ | JAK2 | O60674 | 1/20 | 0.46 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.45 |
| ▸ | METAP2 | P50579 | 1/20 | 0.45 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.45 |
| ▸ | CLK1 | P49759 | 1/20 | 0.45 |
| ▸ | CLK2 | P49760 | 1/20 | 0.45 |
| ▸ | CLK3 | P49761 | 1/20 | 0.45 |
| ▸ | GSK3B | P49841 | 1/20 | 0.45 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.45 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Indazole SCHEMBL2267429 | 1.00 | HSP90AA1 (0.66) | HSP90AA1IDO1CDK2ABCB1CTNNB1 | |
| Indazole SCHEMBL20239569 | 1.00 | HSP90AA1 (0.66) | HSP90AA1IDO1CDK2ABCB1CTNNB1 | |
| Indazole SCHEMBL29627950 | 1.00 | HSP90AA1 (0.66) | HSP90AA1IDO1CDK2ABCB1CTNNB1 | |
| Indazole SCHEMBL8415085 | 0.87 | HSP90AA1 (0.79) | HSP90AA1IDO1CDK2ABCB1CTNNB1 | |
| Indazole SCHEMBL28043445 | 0.85 | HSP90AA1 (0.76) | HSP90AA1IDO1CDK2ABCB1CTNNB1 | |
| Indazole SCHEMBL1162915 | 0.85 | HSP90AA1 (0.76) | HSP90AA1IDO1CDK2ABCB1CTNNB1 | |
| Indazole SCHEMBL1574644 | 0.84 | HSP90AA1 (0.73) | HSP90AA1IDO1CDK2ABCB1CTNNB1 | |
| Indazole SCHEMBL2029058 | 0.84 | HSP90AA1 (0.73) | HSP90AA1IDO1CDK2ABCB1CTNNB1 | |
| Indazole SCHEMBL27865905 | 0.84 | HSP90AA1 (0.73) | HSP90AA1IDO1CDK2ABCB1CTNNB1 | |
| Indazole SCHEMBL1854887 | 0.84 | HSP90AA1 (0.73) | HSP90AA1IDO1CDK2ABCB1CTNNB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110201657-A1 | AMIDE SUBSTITUTED INDAZOLE AND BENZOTRIAZOLE DERIVATIVES AS POLY(ADP-RIBOSE)POLYMERASE (PARP) INHIBITORS | ISTITUTO DI RICERCHE DI BIOLOGIA MOLECOLARE P. ANGELETTI SPA (IT) | 2011-08-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110201657-A1 | AMIDE SUBSTITUTED INDAZOLE AND BENZOTRIAZOLE DERIVATIVES AS POLY(ADP-RIBOSE)POLYMERASE (PARP) INHIBITORS | PARP1, PARP3, PARP2 | HSP90AA1 2088/4885IDO1 528/4885CDK2 187/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.