Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 20/20 | 0.88 |
| ▸ | MTOR | P42345 | 13/20 | 0.88 |
| ▸ | PIK3CB | P42338 | 11/20 | 0.88 |
| ▸ | PIK3CD | O00329 | 10/20 | 0.88 |
| ▸ | PIK3CG | P48736 | 10/20 | 0.88 |
| ▸ | PIK3C2A | O00443 | 1/20 | 0.80 |
| ▸ | PIK3C2B | O00750 | 1/20 | 0.80 |
| ▸ | STK10 | O94804 | 1/20 | 0.80 |
| ▸ | PAK4 | O96013 | 1/20 | 0.80 |
| ▸ | ABL1 | P00519 | 1/20 | 0.80 |
| ▸ | EGFR | P00533 | 1/20 | 0.80 |
| ▸ | FGR | P09769 | 1/20 | 0.80 |
| ▸ | FER | P16591 | 1/20 | 0.80 |
| ▸ | PRKCA | P17252 | 1/20 | 0.80 |
| ▸ | JAK1 | P23458 | 1/20 | 0.80 |
| ▸ | TEC | P42680 | 1/20 | 0.80 |
| ▸ | SYK | P43405 | 1/20 | 0.80 |
| ▸ | PRKDC | P78527 | 1/20 | 0.80 |
| ▸ | MAP3K9 | P80192 | 1/20 | 0.80 |
| ▸ | BTK | Q06187 | 1/20 | 0.80 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1180687 | 0.93 | PIK3CA (1.00) | PIK3CAMTORPIK3CBPIK3CDPIK3CG | |
| SCHEMBL1182230 | 0.93 | PIK3CA (1.00) | PIK3CAMTORPIK3CBPIK3CDPIK3CG | |
| SCHEMBL1180533 | 0.91 | PIK3CA (0.84) | PIK3CAMTORPIK3CBPIK3CDPIK3CG | |
| SCHEMBL1181030 | 0.91 | PIK3CA (0.84) | PIK3CAMTORPIK3CBPIK3CDPIK3CG | |
| SCHEMBL1181593 | 0.90 | PIK3CA (0.82) | PIK3CAMTORPIK3CBPIK3CDPIK3CG | |
| SCHEMBL1182064 | 0.89 | PIK3CA (1.00) | PIK3CAMTORPIK3CBPIK3CDPIK3CG | |
| SCHEMBL20383005 | 0.89 | PIK3CA (0.80) | PIK3CAMTORPIK3CBPIK3CDPIK3CG | |
| SCHEMBL19705763 | 0.89 | PIK3CA (0.80) | PIK3CAMTORPIK3CBPIK3CDPIK3CG | |
| Apitolisib SCHEMBL466297 | 0.89 | PIK3CA (1.00) | PIK3CAMTORPIK3CBPIK3CDPIK3CG | |
| SCHEMBL1181040 | 0.89 | PIK3CA (1.00) | PIK3CAMTORPIK3CBPIK3CDPIK3CG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20200360386-A1 | Inhibitors of HSP90, PI3-Kinase, Proteasome, HDAC, and P97 Pathways for Selective Removal of Senescent Cells in the Treatment of Age Related Conditions | UNITY BIOTECHNOLOGY, INC. | 2020-11-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200360386-A1 | Inhibitors of HSP90, PI3-Kinase, Proteasome, HDAC, and P97 Pathways for Selective Removal of Senescent Cells in the Treatment of Age Related Conditions | HSP90AB1, HSP90AB2P, HSP90AA1 | PIK3CA 156/4885MTOR 16/4885PIK3CB 302/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.