Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 9/20 | 0.37 |
| ▸ | EGFR | P00533 | 9/20 | 0.37 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.37 |
| ▸ | FGFR2 | P21802 | 2/20 | 0.37 |
| ▸ | FGFR4 | P22455 | 2/20 | 0.37 |
| ▸ | FGFR3 | P22607 | 2/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | RET | P07949 | 3/20 | 0.35 |
| ▸ | KDR | P35968 | 2/20 | 0.35 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.33 |
| ▸ | PDE6D | O43924 | 1/20 | 0.33 |
| ▸ | PDE6A | P16499 | 1/20 | 0.33 |
| ▸ | PDE6G | P18545 | 1/20 | 0.33 |
| ▸ | PDE6B | P35913 | 1/20 | 0.33 |
| ▸ | PDE6C | P51160 | 1/20 | 0.33 |
| ▸ | PDE6H | Q13956 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25129682 | 0.89 | FGFR1 (0.48) | BTKEGFRFGFR1FGFR2FGFR4 | |
| SCHEMBL30303832 | 0.89 | FGFR1 (0.48) | BTKEGFRFGFR1FGFR2FGFR4 | |
| SCHEMBL22676244 | 0.77 | FGFR1 (0.54) | BTKEGFRFGFR1FGFR2FGFR4 | |
| SCHEMBL30304065 | 0.77 | FGFR1 (0.54) | BTKEGFRFGFR1FGFR2FGFR4 | |
| SCHEMBL26085293 | 0.76 | FGFR1 (0.51) | BTKEGFRFGFR1FGFR2FGFR4 | |
| SCHEMBL22676381 | 0.75 | FGFR1 (0.52) | FGFR1FGFR2FGFR4FGFR3CYP3A4 | |
| SCHEMBL30303266 | 0.75 | FGFR1 (0.52) | FGFR1FGFR2FGFR4FGFR3CYP3A4 | |
| SCHEMBL22675772 | 0.74 | FGFR1 (0.59) | BTKEGFRFGFR1FGFR2FGFR4 | |
| SCHEMBL30303482 | 0.74 | FGFR1 (0.59) | BTKEGFRFGFR1FGFR2FGFR4 | |
| SCHEMBL22675769 | 0.73 | FGFR1 (0.52) | BTKFGFR1FGFR2FGFR4FGFR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020231990-A1 | FGFR INHIBITORS AND METHODS OF USE THEREOF | RELAY THERAPEUTICS, INC. (US) | 2020-11-19 | — | — | WO | disclosed |