Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR1 | P11362 | 2/20 | 1.00 |
| ▸ | FGFR2 | P21802 | 2/20 | 1.00 |
| ▸ | FGFR4 | P22455 | 2/20 | 1.00 |
| ▸ | FGFR3 | P22607 | 2/20 | 1.00 |
| ▸ | CYP3A4 | P08684 | 1/20 | 1.00 |
| ▸ | CYP2D6 | P10635 | 1/20 | 1.00 |
| ▸ | CYP2C9 | P11712 | 1/20 | 1.00 |
| ▸ | CYP2C19 | P33261 | 1/20 | 1.00 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | ALOX5AP | P20292 | 2/20 | 0.37 |
| ▸ | FEN1 | P39748 | 2/20 | 0.37 |
| ▸ | JAK3 | P52333 | 3/20 | 0.35 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.35 |
| ▸ | KDR | P35968 | 5/20 | 0.34 |
| ▸ | AXL | P30530 | 3/20 | 0.34 |
| ▸ | MET | P08581 | 2/20 | 0.34 |
| ▸ | KIT | P10721 | 2/20 | 0.34 |
| ▸ | AURKA | O14965 | 1/20 | 0.34 |
| ▸ | IKBKE | Q14164 | 1/20 | 0.34 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Lirafugratinib SCHEMBL30303579 | 1.00 | FGFR1 (1.00) | FGFR1FGFR2FGFR4FGFR3CYP3A4 | |
| Lirafugratinib SCHEMBL29728045 | 0.99 | FGFR1 (0.99) | FGFR1FGFR2FGFR4FGFR3CYP3A4 | |
| SCHEMBL30303634 | 0.93 | FGFR1 (0.87) | FGFR1FGFR2FGFR4FGFR3CYP3A4 | |
| SCHEMBL22676905 | 0.93 | FGFR1 (0.87) | FGFR1FGFR2FGFR4FGFR3CYP3A4 | |
| SCHEMBL30586234 | 0.93 | FGFR1 (0.86) | FGFR1FGFR2FGFR4FGFR3CYP3A4 | |
| SCHEMBL22677202 | 0.93 | FGFR1 (0.86) | FGFR1FGFR2FGFR4FGFR3CYP3A4 | |
| SCHEMBL22676895 | 0.93 | FGFR1 (0.86) | FGFR1FGFR2FGFR4FGFR3CYP3A4 | |
| SCHEMBL30303773 | 0.93 | FGFR1 (0.86) | FGFR1FGFR2FGFR4FGFR3CYP3A4 | |
| SCHEMBL22676907 | 0.93 | FGFR1 (0.86) | FGFR1FGFR2FGFR4FGFR3CYP3A4 | |
| SCHEMBL30303341 | 0.93 | FGFR1 (0.86) | FGFR1FGFR2FGFR4FGFR3CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4306529-A2 | FGFR INHIBITORS AND METHODS OF USE THEREOF | Relay Therapeutics, Inc. (US) | 2024-01-17 | — | — | EP | disclosed |
| US-11780845-B2 | FGFR inhibitors and methods of use thereof | RELAY THERAPEUTICS, INC. (US) | 2023-10-10 | — | — | US | disclosed |
| US-11780845-B2 | FGFR inhibitors and methods of use thereof | RELAY THERAPEUTICS, INC. (US) | 2023-10-10 | — | — | US | disclosed |
| US-20230192709-A1 | FGFR INHIBITORS AND METHODS OF USE THEREOF | RELAY THERAPEUTICS, INC. | 2023-06-22 | — | — | US | disclosed |
| US-20230192709-A1 | FGFR INHIBITORS AND METHODS OF USE THEREOF | RELAY THERAPEUTICS, INC. | 2023-06-22 | — | — | US | disclosed |
| WO-2023078413-A1 | FGFR2 INHIBITOR, PREPARATION METHOD THEREFOR, AND PHARMACEUTICAL USE THEREOF | 微境生物医药科技(上海)有限公司 | 2023-05-11 | — | — | WO | disclosed |
| US-20230104574-A1 | FGFR INHIBITORS AND METHODS OF USE THEREOF | D.E. SHAW RESEARCH, LLC | 2023-04-06 | — | — | US | disclosed |
| US-20220194946-A1 | FGFR INHIBITORS AND METHODS OF MAKING AND USING THE SAME | RELAY THERAPEUTICS, INC. | 2022-06-23 | — | — | US | disclosed |
| WO-2022109577-A1 | FGFR INHIBITORS AND METHODS OF MAKING AND USING THE SAME | RELAY THERAPEUTICS, INC. (US) | 2022-05-27 | — | — | WO | disclosed |
| WO-2020231990-A1 | FGFR INHIBITORS AND METHODS OF USE THEREOF | RELAY THERAPEUTICS, INC. (US) | 2020-11-19 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230192709-A1 | FGFR INHIBITORS AND METHODS OF USE THEREOF | FGFR3, FGFR2, FGFR1 | FGFR1 3/4885FGFR2 2/4885FGFR4 4/4885 |
| US-20230104574-A1 | FGFR INHIBITORS AND METHODS OF USE THEREOF | FGFR3, FGFR2, FGFR1 | FGFR1 3/4885FGFR2 2/4885FGFR4 4/4885 |
| US-11780845-B2 | FGFR inhibitors and methods of use thereof | FGFR3, FGFR2, FGFR1 | FGFR1 3/4885FGFR2 2/4885FGFR4 4/4885 |
| US-20220194946-A1 | FGFR INHIBITORS AND METHODS OF MAKING AND USING THE SAME | FGFR3, FGFR2, FGFR1 | FGFR1 3/4885FGFR2 2/4885FGFR4 4/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.