Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR1 | P11362 | 2/20 | 0.55 |
| ▸ | FGFR2 | P21802 | 2/20 | 0.55 |
| ▸ | FGFR4 | P22455 | 2/20 | 0.55 |
| ▸ | FGFR3 | P22607 | 2/20 | 0.55 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.55 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.55 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.55 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.55 |
| ▸ | JAK2 | O60674 | 2/20 | 0.42 |
| ▸ | MET | P08581 | 3/20 | 0.39 |
| ▸ | AXL | P30530 | 2/20 | 0.39 |
| ▸ | FLT3 | P36888 | 1/20 | 0.37 |
| ▸ | SRC | P12931 | 2/20 | 0.37 |
| ▸ | ABL1 | P00519 | 1/20 | 0.37 |
| ▸ | KIT | P10721 | 3/20 | 0.36 |
| ▸ | KDR | P35968 | 3/20 | 0.36 |
| ▸ | TEK | Q02763 | 3/20 | 0.36 |
| ▸ | AURKA | O14965 | 1/20 | 0.36 |
| ▸ | IKBKE | Q14164 | 1/20 | 0.36 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30303817 | 0.88 | FGFR1 (0.70) | FGFR1FGFR2FGFR4FGFR3CYP3A4 | |
| SCHEMBL22676726 | 0.88 | FGFR1 (0.70) | FGFR1FGFR2FGFR4FGFR3CYP3A4 | |
| SCHEMBL22676429 | 0.81 | FGFR1 (0.78) | FGFR1FGFR2FGFR4FGFR3CYP3A4 | |
| SCHEMBL30303752 | 0.81 | FGFR1 (0.78) | FGFR1FGFR2FGFR4FGFR3CYP3A4 | |
| SCHEMBL22677856 | 0.81 | FGFR1 (0.62) | FGFR1FGFR2FGFR4FGFR3CYP3A4 | |
| SCHEMBL30303755 | 0.81 | FGFR1 (0.62) | FGFR1FGFR2FGFR4FGFR3CYP3A4 | |
| SCHEMBL30304000 | 0.80 | FGFR1 (0.54) | FGFR1FGFR2FGFR4FGFR3CYP3A4 | |
| SCHEMBL22676728 | 0.80 | FGFR1 (0.68) | FGFR1FGFR2FGFR4FGFR3CYP3A4 | |
| SCHEMBL22676662 | 0.80 | FGFR1 (0.54) | FGFR1FGFR2FGFR4FGFR3CYP3A4 | |
| SCHEMBL30303303 | 0.80 | FGFR1 (0.68) | FGFR1FGFR2FGFR4FGFR3CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020231990-A1 | FGFR INHIBITORS AND METHODS OF USE THEREOF | RELAY THERAPEUTICS, INC. (US) | 2020-11-19 | — | — | WO | disclosed |