Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.43 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.43 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | BTK | Q06187 | 11/20 | 0.38 |
| ▸ | LCK | P06239 | 6/20 | 0.36 |
| ▸ | TEK | Q02763 | 5/20 | 0.36 |
| ▸ | KDR | P35968 | 4/20 | 0.36 |
| ▸ | EGFR | P00533 | 2/20 | 0.35 |
| ▸ | ITK | Q08881 | 2/20 | 0.35 |
| ▸ | JAK3 | P52333 | 1/20 | 0.35 |
| ▸ | BLK | P51451 | 2/20 | 0.35 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.35 |
| ▸ | RET | P07949 | 1/20 | 0.35 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.35 |
| ▸ | FLT3 | P36888 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22675776 | 0.87 | CYP3A4 (0.48) | CYP3A4CYP2D6FGFR1CYP2C9FGFR2 | |
| SCHEMBL30303304 | 0.84 | BTK (0.45) | CYP3A4CYP2D6FGFR1CYP2C9FGFR2 | |
| SCHEMBL22676642 | 0.84 | BTK (0.45) | CYP3A4CYP2D6FGFR1CYP2C9FGFR2 | |
| SCHEMBL22675976 | 0.83 | FGFR1 (0.53) | CYP3A4CYP2D6FGFR1CYP2C9FGFR2 | |
| SCHEMBL30303360 | 0.83 | FGFR1 (0.53) | CYP3A4CYP2D6FGFR1CYP2C9FGFR2 | |
| SCHEMBL30303590 | 0.81 | FGFR1 (0.65) | CYP3A4CYP2D6FGFR1CYP2C9FGFR2 | |
| SCHEMBL22675924 | 0.81 | FGFR1 (0.65) | CYP3A4CYP2D6FGFR1CYP2C9FGFR2 | |
| SCHEMBL30303931 | 0.78 | FGFR1 (0.51) | CYP3A4CYP2D6FGFR1CYP2C9FGFR2 | |
| SCHEMBL22675771 | 0.78 | FGFR1 (0.51) | CYP3A4CYP2D6FGFR1CYP2C9FGFR2 | |
| SCHEMBL25716101 | 0.78 | LCK (0.40) | CYP3A4CYP2D6FGFR1CYP2C9FGFR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4306529-A2 | FGFR INHIBITORS AND METHODS OF USE THEREOF | Relay Therapeutics, Inc. (US) | 2024-01-17 | — | — | EP | disclosed |
| WO-2020231990-A1 | FGFR INHIBITORS AND METHODS OF USE THEREOF | RELAY THERAPEUTICS, INC. (US) | 2020-11-19 | — | — | WO | disclosed |