Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 3/20 | 0.41 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.40 |
| ▸ | FGFR2 | P21802 | 2/20 | 0.40 |
| ▸ | FGFR4 | P22455 | 2/20 | 0.40 |
| ▸ | FGFR3 | P22607 | 2/20 | 0.40 |
| ▸ | JAK2 | O60674 | 1/20 | 0.39 |
| ▸ | RIPK2 | O43353 | 2/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | RET | P07949 | 4/20 | 0.37 |
| ▸ | NEK7 | Q8TDX7 | 1/20 | 0.35 |
| ▸ | CCNK | O75909 | 2/20 | 0.35 |
| ▸ | CDK12 | Q9NYV4 | 2/20 | 0.35 |
| ▸ | EGFR | P00533 | 2/20 | 0.35 |
| ▸ | ERBB2 | P04626 | 2/20 | 0.35 |
| ▸ | ERBB3 | P21860 | 2/20 | 0.35 |
| ▸ | TEK | Q02763 | 2/20 | 0.35 |
| ▸ | ERBB4 | Q15303 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22676463 | 0.89 | FGFR1 (0.51) | BTKFGFR1FGFR2FGFR4FGFR3 | |
| SCHEMBL25129380 | 0.89 | FGFR1 (0.51) | BTKFGFR1FGFR2FGFR4FGFR3 | |
| SCHEMBL22677970 | 0.84 | FGFR1 (0.52) | BTKFGFR1FGFR2FGFR4FGFR3 | |
| SCHEMBL30303378 | 0.84 | FGFR1 (0.52) | BTKFGFR1FGFR2FGFR4FGFR3 | |
| SCHEMBL22676992 | 0.83 | FGFR1 (0.52) | BTKFGFR1FGFR2FGFR4FGFR3 | |
| SCHEMBL22676379 | 0.82 | HPGD (0.45) | BTKFGFR1FGFR2FGFR4FGFR3 | |
| SCHEMBL22677825 | 0.82 | FGFR1 (0.50) | BTKFGFR1FGFR2FGFR4FGFR3 | |
| SCHEMBL22676919 | 0.80 | FGFR1 (0.47) | BTKFGFR1FGFR2FGFR4FGFR3 | |
| SCHEMBL25129235 | 0.79 | FGFR1 (0.43) | BTKFGFR1FGFR2FGFR4FGFR3 | |
| SCHEMBL22676166 | 0.78 | FGFR1 (0.52) | BTKFGFR1FGFR2FGFR4FGFR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020231990-A1 | FGFR INHIBITORS AND METHODS OF USE THEREOF | RELAY THERAPEUTICS, INC. (US) | 2020-11-19 | — | — | WO | disclosed |