Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 6/20 | 0.44 |
| ▸ | KIT | P10721 | 5/20 | 0.44 |
| ▸ | FGFR1 | P11362 | 3/20 | 0.44 |
| ▸ | FGFR3 | P22607 | 2/20 | 0.44 |
| ▸ | FLT3 | P36888 | 2/20 | 0.44 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.44 |
| ▸ | AURKA | O14965 | 2/20 | 0.44 |
| ▸ | PLK4 | O00444 | 1/20 | 0.44 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.44 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.44 |
| ▸ | PAK4 | O96013 | 1/20 | 0.44 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.44 |
| ▸ | ABL1 | P00519 | 1/20 | 0.44 |
| ▸ | INSR | P06213 | 1/20 | 0.44 |
| ▸ | LCK | P06239 | 1/20 | 0.44 |
| ▸ | FYN | P06241 | 1/20 | 0.44 |
| ▸ | CSF1R | P07333 | 1/20 | 0.44 |
| ▸ | LYN | P07948 | 1/20 | 0.44 |
| ▸ | IGF1R | P08069 | 1/20 | 0.44 |
| ▸ | MET | P08581 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22676848 | 0.83 | PLK4 (0.41) | KDRKITFGFR1FGFR3FLT3 | |
| SCHEMBL22676814 | 0.82 | FGFR1 (0.40) | KDRKITFGFR1FGFR3FLT3 | |
| SCHEMBL30303770 | 0.80 | KDR (0.44) | KDRKITFGFR1FGFR3FLT3 | |
| SCHEMBL22676017 | 0.80 | KDR (0.44) | KDRKITFGFR1FGFR3FLT3 | |
| SCHEMBL22677013 | 0.75 | KIT (0.45) | KDRKITFGFR1FGFR3FLT3 | |
| SCHEMBL22676849 | 0.72 | KDR (0.43) | KDRKITFGFR1FGFR3FLT3 | |
| SCHEMBL30303274 | 0.72 | KDR (0.43) | KDRKITFGFR1FGFR3FLT3 | |
| SCHEMBL22675820 | 0.72 | KDR (0.44) | KDRKITFGFR1FGFR3FLT3 | |
| SCHEMBL30303526 | 0.72 | KDR (0.44) | KDRKITFGFR1FGFR3FLT3 | |
| SCHEMBL26084585 | 0.72 | KDR (0.44) | KDRKITFGFR1FGFR3FLT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4306529-A2 | FGFR INHIBITORS AND METHODS OF USE THEREOF | Relay Therapeutics, Inc. (US) | 2024-01-17 | — | — | EP | disclosed |
| WO-2020231990-A1 | FGFR INHIBITORS AND METHODS OF USE THEREOF | RELAY THERAPEUTICS, INC. (US) | 2020-11-19 | — | — | WO | disclosed |