Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DCLK1 | O15075 | 2/20 | 0.52 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.52 |
| ▸ | MAPK7 | Q13164 | 1/20 | 0.50 |
| ▸ | TNK2 | Q07912 | 3/20 | 0.49 |
| ▸ | STAT6 | P42226 | 1/20 | 0.47 |
| ▸ | CCND3 | P30281 | 3/20 | 0.47 |
| ▸ | CCNA2 | P20248 | 2/20 | 0.47 |
| ▸ | CDK2 | P24941 | 2/20 | 0.47 |
| ▸ | CCNK | O75909 | 1/20 | 0.47 |
| ▸ | CDK9 | P50750 | 1/20 | 0.47 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.47 |
| ▸ | JAK2 | O60674 | 1/20 | 0.46 |
| ▸ | JAK1 | P23458 | 1/20 | 0.46 |
| ▸ | TYK2 | P29597 | 1/20 | 0.46 |
| ▸ | JAK3 | P52333 | 1/20 | 0.46 |
| ▸ | IGF1R | P08069 | 2/20 | 0.46 |
| ▸ | CDK4 | P11802 | 3/20 | 0.44 |
| ▸ | CCND1 | P24385 | 2/20 | 0.44 |
| ▸ | CCND2 | P30279 | 2/20 | 0.44 |
| ▸ | PKMYT1 | Q99640 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22680779 | 0.93 | DCLK1 (0.49) | DCLK1LRRK2MAPK7TNK2STAT6 | |
| SCHEMBL22680883 | 0.93 | TNK2 (0.56) | DCLK1LRRK2MAPK7TNK2CCND3 | |
| SCHEMBL22680895 | 0.93 | LRRK2 (0.51) | DCLK1LRRK2MAPK7TNK2CDK6 | |
| SCHEMBL22680785 | 0.89 | DCLK1 (0.50) | DCLK1LRRK2MAPK7TNK2CCND3 | |
| SCHEMBL22680790 | 0.87 | LRRK2 (0.69) | DCLK1LRRK2MAPK7TNK2IGF1R | |
| SCHEMBL22680698 | 0.82 | STK4 (0.63) | DCLK1LRRK2MAPK7AURKAAURKB | |
| SCHEMBL17469560 | 0.82 | DCLK1 (0.51) | DCLK1LRRK2MAPK7TNK2CCND3 | |
| SCHEMBL22680789 | 0.79 | LRRK2 (0.69) | DCLK1LRRK2MAPK7TNK2 | |
| SCHEMBL17465883 | 0.78 | DCLK1 (0.78) | DCLK1LRRK2MAPK7TNK2PTK2 | |
| SCHEMBL23998661 | 0.75 | STK4 (0.68) | DCLK1LRRK2SYKAURKAAURKB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11279707-B2 | NEK inhibitors and methods of use | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2022-03-22 | — | — | US | disclosed |
| US-20200361948-A1 | NEK INHIBITORS AND METHODS OF USE | DANA-FARBER CANCER INSTITUTE, INC. | 2020-11-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200361948-A1 | NEK INHIBITORS AND METHODS OF USE | NEK5, NEK2, NEK1 | DCLK1 188/4885LRRK2 3010/4885MAPK7 911/4885 |
| US-11279707-B2 | NEK inhibitors and methods of use | NEK5, NEK2, NEK1 | DCLK1 188/4885LRRK2 3010/4885MAPK7 911/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.