Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP19A1 | P11511 | 1/20 | 0.44 |
| ▸ | ABCG2 | Q9UNQ0 | 10/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.39 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.39 |
| ▸ | CFTR | P13569 | 1/20 | 0.38 |
| ▸ | CA12 | O43570 | 1/20 | 0.38 |
| ▸ | CA1 | P00915 | 1/20 | 0.38 |
| ▸ | CA2 | P00918 | 1/20 | 0.38 |
| ▸ | CA9 | Q16790 | 1/20 | 0.38 |
| ▸ | KIF11 | P52732 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17199253 | 0.94 | CYP19A1 (0.49) | CYP19A1ABCG2MEN1KMT2ALMNA | |
| SCHEMBL17199125 | 0.89 | GRIK1 (0.45) | ABCG2MEN1KMT2AMAPTCYP1A2 | |
| SCHEMBL17199149 | 0.82 | CYP19A1 (0.49) | CYP19A1MEN1KMT2ALMNAMAPT | |
| SCHEMBL2425532 | 0.80 | CYP19A1 (0.52) | CYP19A1ABCG2MEN1KMT2ALMNA | |
| SCHEMBL2421702 | 0.78 | CYP19A1 (0.69) | CYP19A1MEN1KMT2ALMNASMN1; SMN2 | |
| SCHEMBL17199186 | 0.78 | CYP19A1 (0.52) | CYP19A1MEN1KMT2ALMNAMAPT | |
| SCHEMBL18470554 | 0.76 | GRIK1 (0.46) | KMT2AMAPK14 | |
| SCHEMBL17199129 | 0.76 | GRIK1 (0.45) | MEN1KMT2AMAPTKIF11 | |
| SCHEMBL18523466 | 0.75 | CYP19A1 (0.61) | CYP19A1MEN1KMT2ALMNAMAPT | |
| SCHEMBL2419878 | 0.74 | CYP19A1 (0.52) | CYP19A1MEN1KMT2ALMNAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3133068-B1 | AMIDE DERIVATIVES AND PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF, PREPARATION METHOD THEREFOR AND MEDICINAL APPLICATION THEREOF | Shanghai hengrui pharmaceutical co ltd (CN) | 2020-11-25 | — | — | EP | disclosed |