Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DDB1 | Q16531 | 2/20 | 0.45 |
| ▸ | CRBN | Q96SW2 | 2/20 | 0.45 |
| ▸ | TNF | P01375 | 1/20 | 0.45 |
| ▸ | IL1B | P01584 | 1/20 | 0.45 |
| ▸ | IKZF3 | Q9UKT9 | 1/20 | 0.45 |
| ▸ | P2RX7 | Q99572 | 14/20 | 0.32 |
| ▸ | JAK2 | O60674 | 1/20 | 0.32 |
| ▸ | JAK3 | P52333 | 1/20 | 0.32 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.30 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.30 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.30 |
| ▸ | TSHR | P16473 | 2/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.30 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21671655 | 0.90 | CRBN (0.56) | DDB1CRBNTNFIL1BIKZF3 | |
| SCHEMBL21671654 | 0.90 | CRBN (0.56) | DDB1CRBNTNFIL1BIKZF3 | |
| SCHEMBL21671659 | 0.79 | CRBN (0.53) | DDB1CRBNTNFIL1BIKZF3 | |
| SCHEMBL21671658 | 0.79 | CRBN (0.53) | DDB1CRBNTNFIL1BIKZF3 | |
| SCHEMBL21671784 | 0.78 | CRBN (0.52) | DDB1CRBNTNFIL1BIKZF3 | |
| SCHEMBL21671783 | 0.78 | CRBN (0.52) | DDB1CRBNTNFIL1BIKZF3 | |
| SCHEMBL25477252 | 0.75 | DDB1 (0.56) | DDB1CRBNTNFIL1BIKZF3 | |
| SCHEMBL21671662 | 0.75 | CRBN (0.58) | DDB1CRBNTNFIL1BIKZF3 | |
| SCHEMBL21671635 | 0.75 | CRBN (0.58) | DDB1CRBNTNFIL1BIKZF3 | |
| SCHEMBL21671752 | 0.75 | CRBN (0.70) | DDB1CRBNTNFIL1BIKZF3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3404024-B1 | QUINAZOLINONE DERIVATIVE, PREPARATION METHOD THEREFOR, PHARMACEUTICAL COMPOSITION, AND APPLICATIONS | KANGPU BIOPHARMACEUTICALS LTD (CN) | 2020-11-18 | — | — | EP | disclosed |