Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR4A2 | P43354 | 1/20 | 0.43 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | PDGFRB | P09619 | 4/20 | 0.41 |
| ▸ | FLT4 | P35916 | 4/20 | 0.41 |
| ▸ | KDR | P35968 | 4/20 | 0.41 |
| ▸ | FLT3 | P36888 | 4/20 | 0.41 |
| ▸ | PLK4 | O00444 | 3/20 | 0.41 |
| ▸ | AURKA | O14965 | 3/20 | 0.41 |
| ▸ | SRC | P12931 | 3/20 | 0.41 |
| ▸ | TEK | Q02763 | 3/20 | 0.41 |
| ▸ | AURKB | Q96GD4 | 3/20 | 0.41 |
| ▸ | NUAK1 | O60285 | 2/20 | 0.41 |
| ▸ | EGFR | P00533 | 2/20 | 0.41 |
| ▸ | INSR | P06213 | 2/20 | 0.41 |
| ▸ | IGF1R | P08069 | 2/20 | 0.41 |
| ▸ | KIT | P10721 | 2/20 | 0.41 |
| ▸ | CDK4 | P11802 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25120758 | 0.77 | STING1 (0.43) | KMT2ASTING1KDM4EALDH1A1 | |
| SCHEMBL25120800 | 0.74 | CCR6 (0.41) | KMT2ACDK4CCND1ABL1CDK2 | |
| SCHEMBL25120724 | 0.74 | STING1 (0.41) | MEN1KMT2ACDK4CCND1STING1 | |
| SCHEMBL6654114 | 0.74 | ATM (0.52) | NR4A2CREBBPMEN1KMT2ASTING1 | |
| SCHEMBL22700001 | 0.73 | STING1 (0.42) | NR4A2MEN1KMT2ACDK4CCND1 | |
| SCHEMBL25120782 | 0.73 | STING1 (0.60) | KMT2APDGFRBSTING1SMN1; SMN2TP53 | |
| SCHEMBL25120874 | 0.73 | STING1 (0.43) | NR4A2CREBBPKMT2ASTING1KDM4E | |
| SCHEMBL22699991 | 0.72 | PLK1 (0.43) | PLK4GSK3BSTING1 | |
| SCHEMBL22699992 | 0.72 | PLK1 (0.43) | PLK4GSK3BSTING1 | |
| SCHEMBL22699986 | 0.72 | PLK1 (0.43) | PLK4GSK3BSTING1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020236586-A1 | N-HETARYL-SQUARAMIDE COMPOUNDS FOR TREATING CONDITIONS ASSOCIATED WITH STING ACTIVITY | IFM DUE, INC. (US) | 2020-11-26 | — | — | WO | disclosed |
| WO-2020236586-A1 | N-HETARYL-SQUARAMIDE COMPOUNDS FOR TREATING CONDITIONS ASSOCIATED WITH STING ACTIVITY | IFM DUE, INC. (US) | 2020-11-26 | — | — | WO | disclosed |