Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTOR | P42345 | 5/20 | 0.52 |
| ▸ | PIK3CA | P42336 | 5/20 | 0.49 |
| ▸ | PIK3CG | P48736 | 3/20 | 0.49 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.49 |
| ▸ | BRAF | P15056 | 4/20 | 0.44 |
| ▸ | TTBK1 | Q5TCY1 | 1/20 | 0.43 |
| ▸ | TTBK2 | Q6IQ55 | 1/20 | 0.43 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.43 |
| ▸ | KDR | P35968 | 4/20 | 0.42 |
| ▸ | RAF1 | P04049 | 1/20 | 0.42 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.42 |
| ▸ | LCK | P06239 | 1/20 | 0.42 |
| ▸ | TEK | Q02763 | 1/20 | 0.42 |
| ▸ | DHODH | Q02127 | 1/20 | 0.41 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.41 |
| ▸ | CLK1 | P49759 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19233401 | 0.85 | BRAF (0.49) | MTORPIK3CAPIK3CGPIK3CDBRAF | |
| SCHEMBL114500 | 0.84 | MTOR (0.74) | MTORPIK3CAPIK3CGPIK3CDBRAF | |
| SCHEMBL19233387 | 0.82 | MTOR (0.44) | MTORPIK3CAPIK3CGPIK3CDBRAF | |
| SCHEMBL114187 | 0.81 | PIK3CA (0.76) | MTORPIK3CAPIK3CGPIK3CDPIK3CB | |
| SCHEMBL891009 | 0.79 | TTBK1 (0.57) | TTBK1TTBK2DYRK1A | |
| SCHEMBL19233303 | 0.79 | KDR (0.49) | MTORPIK3CAPIK3CGPIK3CDBRAF | |
| SCHEMBL28668955 | 0.79 | MTOR (0.43) | MTORPIK3CAPIK3CGPIK3CDBRAF | |
| SCHEMBL24885729 | 0.78 | BRAF (0.46) | MTORPIK3CAPIK3CGPIK3CDBRAF | |
| SCHEMBL30078235 | 0.78 | BRAF (0.46) | MTORPIK3CAPIK3CGPIK3CDBRAF | |
| SCHEMBL19233202 | 0.78 | KDR (0.51) | MTORPIK3CAPIK3CGPIK3CDBRAF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10844062-B2 | Pyridine derivative inhibiting RAF kinase and vascular endothelial growth factor receptor, method for preparing same, pharmaceutical composition containing same, and use thereof | INCHEON UNIVERSITY INDUSTRY ACADEMIC COOPERATION FOUNDATION (KR) | 2020-11-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10844062-B2 | Pyridine derivative inhibiting RAF kinase and vascular endothelial growth factor receptor, method for preparing same, pharmaceutical composition containing same, and use thereof | BRAF, KDR, RAF1 | MTOR 1009/4885PIK3CA 108/4885PIK3CG 322/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.